Cervical cancer is a disease characterized by the growth of abnormal cells in cervical tissue. mostly caused Human Papillomavirus (HPV) types 16 and 18. The role genetic factors development malignancy mediated presence mutation HPV oncogene, especially oncogenes E6 E7. Oncogenic proteins E7 initiate dysregulation cellular proliferation apoptotic mechanisms targeting tumor suppressor proteins, s...

Intracranial Fibroblastic neoplasms developed in 16 of 19 hamsters inoculated intracerebrally with bovine papilloma virus. The tumors presumably arose in the meninges and infiltrated the adjacent brain along the vascular channels. Tumor nodules that developed in the subcutis of the extremities, ears, and body were probably due to viremia following intracerebral inoculation. Fibroblasts of the c...

The pronounced resistance to the x-rays manifested by the papilloma virus in ordinary suspensions is due to the protecting influence of extraneous matter and also in considerable degree to the amount of virus present in the preparation. Two to 4 million r were required to inactivate the virus contained in the crude papilloma extracts prepared for the present work, whereas 100,000 r or less was ...

Intracranial Fibroblastic neoplasms developed in 16 of 19 hamsters inoculated intracerebrally with bovine papilloma virus. The tumors presumably arose in the meninges and infiltrated the adjacent brain along the vascular channels. Tumor nodules that developed in the subcutis of the extremities, ears, and body were probably due to viremia following intracerebral inoculation. Fibroblasts of the c...

Ubiquitination is one of the most important post-translational modifications of proteins with a profound effect on their intracellular stability and activity. Deubiquitinases (DUBs), on the other hand, act by removing the ubiquitin moiety from proteins and thereby reverse their stability and/or activity. Besides, DUBs play a major role in maintenance of free ubiquitin pool, histone modification...

Cellular retinole acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specific ity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly higher than that in the normal rabbit skin and increased in accordance with t...

We report a case of 68-year-old woman suffering from breathlessness on exertion with stridor. A chest computed tomography showed a tumor arising from the posterior wall of the trachea. The diagnosis was squamous cell papilloma of the surgically removed tumor, which had caused the asphyxiation. After removal of the tumor, the patient received radical therapy: semiconductor laser transpiration. P...