Focal lesions can affect connectivity between distal brain regions (connectional diaschisis) and impact the graph-theoretic properties of major brain networks (connectomic diaschisis). Given its unique anatomy and diverse range of functions, the hippocampus has been claimed to be a critical "hub" in brain networks. We investigated the effects of hippocampal lesions on structural and functional ...

Traditional resting-state network concept is based on calculating linear dependence of spontaneous low frequency fluctuations of the BOLD signals of different brain areas, which assumes temporally stable zero-lag synchrony across regions. However, growing amount of experimental findings suggest that functional connectivity exhibits dynamic changes and a complex time-lag structure, which cannot ...

Subproject 1: Main objective: The objective of this study was to analyse the network of the functional connectivity map supporting mood disorders: major depressive disorder (MDD) and bipolar disease (BD). The specific aims were: 1) to reverse engineer the functional connectivity map supporting MDD and BD; 2) to develop computational models of the functional connectivity maps of MDD for identify...

Bipolar disorder (BD), a mood disorder characterized by emotional lability and dysregulation, is associated with alterations in functional connectivity, particularly as assessed using functional MRI. Here, we provide an overview of the extant literature, and themes that have emerged within it. We identified published research describing functional connectivity in BD using PubMed and follow-up s...

Brain graphs provide a useful way to computationally model the network structure of the connectome, and this has led to increasing interest in the use of graph theory to quantitate and investigate the topological characteristics of the healthy brain and brain disorders on the network level. The majority of graph theory investigations of functional connectivity have relied on the assumption of t...

Developmental neuroscience, the study of the processes that shape and reshape the maturing brain, is a growing field still in its nascent stages. The developmental application of functional and effective connectivity techniques, which are tools that measure the interactions between elements of the brain, has revealed insight to the developing brain as a complex system. However, this insight is ...

Neural processing is based on interactions between functionally specialized areas that can be described in terms of functional or effective connectivity. Functional connectivity is often assessed by task-free, resting-state functional magnetic resonance imaging (fMRI), whereas effective connectivity is usually estimated from task-based fMRI time-series. To investigate whether different connecti...