Purpose: This case report provides an overview of telehealth delivery our Better Conversations approach to communication partner training (CPT) for people with primary progressive aphasia (PPA) and their (CP). The purpose is advance the knowledge speech language therapists/pathologists (SLTs) on this type CPT empower them deliver teleCPT as part clinical practice. Method: We provide a describin...

This paper develops a method to analyse email communication networks in terms of the effectiveness of emails to elicit a reply. Four factors are considered: the email’s sender (sender effect), the email’s recipients (recipient effect), specific properties of each sender-recipient dyad (dyad effect), and specific properties of the email (stimulus effect). A multilevel model is developed and appl...

The interplay between electrostatic and van der Waals (vdW) interactions in porphyrin-C60 dyads is still under debate despite its importance in influencing the structural characteristics of such complexes considered for various applications in molecular photovoltaics. In this article, we sample the conformational space of a porphyrin-C60 dyad using Car-Parrinello molecular dynamics simulations ...

Serum paraoxonases (PONs) are calcium-dependent lactonases that catalyze the hydrolysis and formation of a variety of lactones, with a clear preference for lipophilic lactones. However, the lactonase mechanism of mammalian PON1, a high density lipoprotein-associated enzyme that is the most studied family member, remains unclear, and other family members have not been examined at all. We present...

The recent re-refinement of the X-ray structure of apo plasmepsin II from Plasmodium falciparum suggests that the two carboxylate groups in the catalytic dyad are noncoplanar, (Robbins et al., Acta Crystallogr D Biol Crystallogr 2009;65: 294-296) in remarkable contrast with the vast majority of structures of aspartic proteases. Here, evidence for the noncoplanarity of the catalytic aspartates i...