RATIONALE Bunyaviruses have become a major threat to both humans and livestock in Europe and the Americas. The nucleocapsid (N) protein of these viruses is key to the replication cycle and knowledge of the N oligomerisation state is central to understanding the viral lifecycle and for development of therapeutic strategies. METHODS Bunyamwera virus and Schmallenberg virus N proteins (BUNV-N an...

Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

Emanuel Edward Klein (1844 - 1925) was a British microbiologist of Croatian origin. He was born in Osijek in what is currently the Republic of Croatia and which was then part of the Habsburg Monarchy, he completed his medical studies in Vienna in 1869, and went on to spend his entire career in London. Although trained as an anatomist, embryologist and histologist, his main area of research was ...

The Right Wing of the Polish emigration after1830 explained disappearance state in 1795 and failure their recent war against tsarist Russia by absence a strong leadership and, particular, king hereditary monarchy. most suitable candidate for was Prince Adam Czartoryski, head right-wing leader as whole. Czartoryski declined title reasons related to his own Hamlet-like character above all, convic...

This article examines the significance of and motives behind projection a distinctively Islamic image King Faruq Egypt in years that followed his ascent to Throne 1936. It argues creation persona al-malik al-salih (the righteous king) was one aspect strategy developed by Ali Mahir Pasha (Prime Minister then Head Royal Diwan) safeguard monarchy an era mass politics. The campaign, however, took o...

The purpose of this essay is to analyse a forgotten work by Sylvain Maréchal, French political writer the Enlightenment. Written on eve Revolution, his Apologues modernes heavily criticize socio-political system monarchy Louis XVI. analysis proves that author does not limit himself criticising situation before 1789, but he clearly predicts events forthcoming revolution and resulting change. One...

This study addresses the issue of history democratic transformation from general dictatorial regime General Francois to his death, which opened door for through gradual political reform, especially after return monarchy led by Juan Carlos. The forces succeeded in light an open policy that believes pluralism, and freedom Parties unions, media guaranteed Constitution issued 1978. In addition thes...