OBJECTIVES Systematic synthesis of the published evidence about incidence, risk factors, and management options for women with ductal carcinoma in situ (DCIS) of the breast. DATA SOURCES Original epidemiologic studies were sought from several databases to identity articles published in English between 1970 and January 31, 2009. REVIEW METHODS Incidence of DCIS in the general population and ...

BACKGROUND This study aimed to assess inter-observer variability between the original diagnostic reports and later review by a specialist in breast pathology considering lobular neoplasias (LN), columnar cell lesions (CCL), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) of the breast. METHODS A retrospective, observational, cross-sectional study was conducted. A total ...

INTRODUCTION Benign Phyllodes Tumours (PTs) are rare fibroepithelial neoplasms that resemble fibroadenoma. But unlike fibroadenoma, benign PT can recur and both stromal & epithelial components can progress to malignancy. Contrary to earlier belief that benign PT is a stromal neoplasm and possibly arises from fibroadenoma, more recent molecular studies have suggested that both stroma and epithel...

Breast cancers are heterogeneous and complex diseases, and subtypes of breast cancers may involve unique molecular mechanisms. The p16(INK4a) and p53 pathways are two of the major pathways involved in control of the cell cycle. They also play key roles in tumorigenesis. However, whether the roles of these pathways differ in the subtypes of breast cancer is unclear. Therefore, p16 and p53 expres...

J-H. Chen, H. J. YU, H-M. Baik, M-Y. Su, O. Nalcioglu Tu &Yuen Center for Functional Onco-Imaging, University of California, Irvine, Irvine, CA 92697, United States, Department of Radiology, China Medical University Hospital, Taichung, Taiwan Purpose Ductal carcinoma in situ (DCIS) accounts for 80% of noninvasive breast carcinomas. Laboratory and patient data suggest that DCIS is a precursor le...

OBJECTIVE To determine the association between thymidine phosphorylase (TP) and angiogenesis, and other conventional prognostic markers. We also evaluated interobserver and intraobserver reliability for TP expression in ductal carcinoma, to achieve a more consistent results. METHODS Our study included all cases diagnosed in Adnan Menderes University Medical Faculty Hospital, Aydin, Turkey as ...

Purpose: Ultrasound-guided core needle biopsy (US CNB) is increasingly used in the histologic evaluation of non-palpable solid breast lesions. We retrospectively investigated the diagnostic accuracy of this technique, using an 18-gauge needle in 422 nonpalpable breast lesions. Materials and Methods: 583 female patients with an average age of 56 (range, 22-90) years underwent 590 US CNBs. Betwee...

Diagnosis of breast preneoplastic and neoplastic lesions is difficult due to their similar morphology in biopsy specimens. To diagnose these lesions, pathologists perform immunohistochemical analysis consult with expert pathologists. These additional examinations are time-consuming expensive. Artificial intelligence (AI)-based image has recently improved, may help ordinal pathological diagnosis...

Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in cancer patients and this feature makes them attractive targets for immunotherapy-based approaches. We have previously reported that CTs are relatively commonly expressed in estr...