BACKGROUND Cancer risk and Lhermitte-Duclos disease (LDD) risk estimates for Cowden syndrome (CS) are broad and based on a small number of patients. Risk estimates are vital to the development of diagnostic criteria, genetic counseling, and cancer surveillance. To further elaborate and estimate the risks associated with CS, a large cohort of patients was evaluated. METHODS CS patients were id...

The existence of discrete spectrum below the essential spectrum is deduced for the Dirichlet Laplacian on tubular neighborhoods (or layers) about hypersurfaces in Rn+1, with various geometric conditions imposed. This is a generalization of the results of Duclos, Exner, and Krejčiřík (2001) in the case of a surface in R3. The key to the generalization is the notion of parabolic manifolds. An int...

_____________________________________ * Corresponding Author Address: Mary Ann Cooper, MD, Department of Emergency Medicine, University of Illinois @ Chicago, M/C 742, 471 CME, 808 S Wood St, Chicago IL, 60612-7354; [email protected] www.uic.edu/labs/lightninginjury Due to underreporting of injuries as well as deaths (Cherington 1999; Duclos 1990,1990a; Holle 2003), it is difficult to pinpoint a...

Here we consider one of the basic models for many-body problems under an external field: the molecule ion H+2 under the effect of an external Stark-type potential. If we consider the vibrational energy levels of the first two electronic states of the molecule ion H+2 then, in the semiclassical limit and by means of a suitable modified Born-Oppenheimer method, we can prove that they switch to sh...

Given a complete non-compact surface Σ embedded in R, we consider the Dirichlet Laplacian in the layer Ω that is defined as a tubular neighbourhood of constant width about Σ. Using an intrinsic approach to the geometry of Ω, we generalise the spectral results of the original paper [1] by Duclos et al. to the situation when Σ does not possess poles. This enables us to consider topologically more...

The next round of reform and cuts to federal taxes should focus on bringing down overall personal tax rates, so that the tax mix depends relatively more on consumption taxes rather than income taxes, says a study released today by the C.D. Howe Institute. And Ottawa should pay more attention to payroll tax design, the study suggests, since payroll taxes that are clearly seen to fund desired ben...

PREMISE OF THE STUDY The Last Glacial Maximum (LGM) was a period of massive range contraction. Post-LGM, water-dispersed coastal species, including the red mangrove (Rhizophora mangle), expanded poleward as propagules were transported by ocean currents. We assessed postglacial marine expansion pathways for R. mangle within the Caribbean Basin and Florida. METHODS Six microsatellite loci were ...

The tumour suppressor gene PTEN encodes a lipid phosphatase, which has been shown to play a crucial role in the regulation of adhesion, migration, growth and apoptosis. PTEN germline mutations have been detected in several familial tumour syndromes, the most prominent of which are Cowden disease (CD) and Bannayan-Zonana (BZ) syndrome. These syndromes are characterised by developmental defects, ...