Diethylenetriaminepentaacetic acid (DTPA) is a useful chelating agent for radionuclides such as (68)Ga, (99m)Tc and (111)In, which are applicable to nuclear medicine imaging. In this study, we established a facile synthetic protocol for the production of mono-DTPA-conjugated peptide probes. A novel monoreactive DTPA precursor reagent was synthesized in two steps using the chemistry of the o-nit...

Application of magnetic resonance imaging (MRI) in two-dimensional quantitative assessment of blood-retinal barrier dysfunction was investigated in rabbits using a 0.1 T (4.25 MHz) resistive system. Reliable and consistent measurements of vitreous T1 were obtained repeatedly, in slices of width 5 mm and X-Y resolution of 1.2 mm. Calibration of reduction of T1 in eyes after injection of gadolini...

Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI rela...

In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with Tc using stannous chloride reducing method. The quality control studies of radiolabeled compound (Tc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) metho...

UNLABELLED The Auger electron-emitting radiopharmaceutical 111In-diethylenetriaminepentaacetic acid human epidermal growth factor (111In-DTPA-hEGF) binds the epidermal growth factor receptor (EGFR), is internalized, and translocates to the nucleus. The purpose of this study was to investigate the relationship between EGFR expression, DNA damage, and cytotoxicity in cells exposed to 111In-DTPA-h...

UNLABELLED The purpose of this study was to evaluate biodistributions and absorbed doses of anti-carcinoembryonic antigen (CEA)/anti-diethylenetriamine pentaacetic acid (DTPA)-indium (anti-DTPA-In) bispecific monoclonal antibody (BsMAb) F6-734 and 125I-labeled DTPA-indium dimer hapten (125I-di-DTPA-In hapten) in athymic mice xenografted with human medullary thyroid cancer. METHODS Bispecific ...

• Extracellular agents (such as Gd-DTPA) accumulate in the interstitium of many tissues (e.g. muscle) but do not cross the normal blood-brain-barrier. • Functional information may be obtained by treating Gd-DTPA as a tracer and following its kinetics (as opposed to the conventional ‘static’ approach, inject wait – image once). • After intravenous administration (normally in the form of a bolus)...

Purpose: Gd-EOB-DTPA is a liver-specific MR imaging contrast agent that is taken up by hepatocytes and excreted into the biliary system. MR cholangiography can be obtained by means of three-dimensional T1-weighted imaging at the optimal scan delay after the injection of Gd-EOB-DTPA (1). The aim of the present study was to evaluate the biliary enhancement dynamics of Gd-EOB-DTPA at MR cholangiog...

Cell tracking using iron oxide nanoparticles has been well established in MRI. However, in experimental rat models, the intrinsic iron signal derived from erythrocytes masks the labeled cells. The research evaluated a clinically applied Gd-DTPA for T1-weighted positive enhancement for cell tracking in spinal cord injury (SCI) rat models. MSCs were labeled with jetPEI/Gd-DTPA particles to evalua...