نتایج جستجو برای: dsb
تعداد نتایج: 3081 فیلتر نتایج به سال:
The repair of DNA double-strand breaks (DSBs) is mediated via two major pathways, nonhomologous end joining (NHEJ) and homologous recombination (HR) repair. DSB repair is vital for cell survival, genome stability, and tumor suppression. In contrast to NHEJ, HR relies on extensive homology and templated DNA synthesis to restore the sequence surrounding the break site. We report a new role for th...
objective: the passage of ionizing radiation in living cells creates clusters of damaged nucleotides in dna. in this study, dna strand breaks induced by the beta particle of iodine-131 (i-131), have been determined experimentally and compared to monte carlo simulation results as a theoretical method of determining131i damage. materials and methods: in this experimental study, in order to create...
Meiosis is the cell division program utilized by most sexually reproducing organisms as a strategy to produce haploid gametes (i.e., sperm and eggs) from diploid parental cells. As suggested by its name, which stems from the Greek word meaning ‘‘to diminish or reduce’’, meiosis reduces the chromosome number by half. This is accomplished by following a single round of DNA replication with two co...
BACKGROUND/AIM The screening of dementia in non-Westerners has so far relied on translations and adaptations of reputed instruments. Other efforts focused on developing culturally appropriate tests or tests in touch with new developments in the field. This study presents the rationale behind the construction of a new dementia screening test: the Dementia Screening Battery-100 (DSB-100). METHO...
Expression of BCR-ABL oncoprotein in chronic myeloid leukemia (CML) promotes neoplastic transformation of hematopoietic stem cells through modulation of diverse pathways. CML is a multistep disease, which evolves as a chronic phase and progresses to blast crisis. This progression has been associated with the appearance and accumulation of new cytogenetic anomalies and mutations. The mechanisms ...
Cellular accumulation of DNA damage has been widely implicated in cellular senescence, aging, and premature aging. In Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD), premature aging is linked to accumulation of DNA double-strand breaks (DSBs), which results in genome instability. However, how DSBs accumulate in cells despite the presence of intact DNA repair protein...
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid double-strand breaks (DSBs), mediated by the RNF8/RNF168 ubiquitin ligases, plays a key role in recruiting repair factors, including 53BP1 and BRCA1, to reestablish genome integrity. In this paper, we show that human RNF169, an uncharacterized E3 ubiquitin ligase paralogous to RNF168, accumulated in DSB repair foci thr...
Genome integrity depends on correct chromosome segregation, which in turn relies on cohesion between sister chromatids from S phase until anaphase. S phase cohesion, together with DNA double-strand break (DSB) recruitment of cohesin and formation of damage-induced (DI) cohesion, has previously been shown to be required also for efficient postreplicative DSB repair. The budding yeast acetyltrans...
In a recent paper, 1 Bridges and Zalewski have discussed an approximate procedure for reducing the interference of one DSB signal upon another when the signals have overlapping spectra. They compared their scheme with various procedures for taking advantage of bandwidth SNR tradeoffs and concluded that it could be used for optimizing bandwidth utilization through the addition and later separati...
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