Purpose: The Narcotics Law as a foundation in law enforcement to eradicate illicit drug trafficking, is not effective enough tackling narcotics crime, because the legal paradigm adopted oriented towards imprisoning perpetrator (follow suspect), while assets resulting from crimes continue be used for trafficking and distribution. problem what urgency of renewing model asset forfeiture crimes? Wh...

Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological functions and drug action; however, robust quantitative approaches are lacking to study such processes in live cells. Here we present new bioluminescence resonance energy transfer (BRET) sensors to quantitatively monitor G protein-coupled receptors (GPCRs) and β-arrestin trafficking. These sensors are b...

BACKGROUND The association between socio-economic marginalisation in urban poor neighbourhoods and the prevalence of violence, crime, drug use and drug dealing has been well documented. However few studies have explored the social context of the transition to, initiation and maintenance of drug injection career in slum areas in developing countries. This study examines the lived experience of y...

P r e s e n t l y t h e r e a r e v a r i o u s transnational crimes which are being committed by the people of the world generally and particularly under the influence of criminal organizations. Drug trafficking, money laundering, trafficking i n w o m e n a n d c h i l d r e n , i l l i c i t manufacturing of and trafficking in fire arms, acts of corruption, use of violence and extortion and ...

Antibody-drug conjugate (ADC) is a milestone in targeted cancer therapy that comprises of monoclonal antibodies chemically linked to cytotoxic drugs. Internalization of ADC takes place via clathrin-mediated endocytosis, caveolae-mediated endocytosis, and pinocytosis. Conjugation strategies, endocytosis and intracellular trafficking optimization, linkers, and drugs chemistry present a great chal...

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding the HERG channel. Several LQT2-associated mutations have been mapped to the amino terminal cytoplasmic Per-Arnt-Sim (PAS) domain of the HERG1a channel subunit. Here we have characterized the trafficking properties of some LQT2-associated PAS domain mutants and analyzed rescue of the trafficking mutants by low t...

Drug trafficking has created many problems for the Central Asian republics and caused significant human financial losses. The high profit prosperity of this trade terrorist extremist religious groups in region to move direction order consolidate their power buy weapons they need use. aim study was investigate effect drug resulting organized crime a descriptive-analytical manner obtain required ...

E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role to facilitate leukocyte cell trafficking by recognizing ligand surface proteins. gained new since it was demonstrated be involved in cancer trafficking, stem-like properties therapy resistance. Therefore, being the tumor microenvironment, can potentially used eradicate cancer. Uproleselan (also know...

Efficient intracellular targeting of drugs and drug delivery systems (DDSs) is a major challenge that should be overcome to enhance the therapeutic efficiency of biopharmaceuticals and other intracellularly-acting drugs. Studies that quantitatively assess the mechanisms, barriers, and efficiency of intracellular drug delivery are required to determine the therapeutic potential of intracellular ...

Abstrak: Peredaran dan penyalahgunaan narkoba semakin marak mengkhawatirkan. Tidak hanya di wilayah perkotaan namun sudah masuk pedesaan. Hal ini menjadikan desa merupakan strategis dalam peredaran narkoba. Kegiatan penyuluhan agama akan dampak bertujuan untuk memberikan pengetahuan penguatan terhadap para remaja, karena remaja adalah cikal bakal kemajuan desa. Mitra dari kegiatan warga Tanjung...