Drug resistance is a significant obstacle to effective cancer treatment. develops from initially reversible drug-tolerant cells, which offer therapeutic opportunities impede relapse. The mechanisms of proteasome inhibitor (PI) therapy have been investigated intensively, however the ways by cells orchestrate their adaptive responses drug challenges remain largely unknown. Here, we demonstrated t...

To assess the prevalence of mutations associated with drug resistance in antiretroviral-naive patients in Kuala Lumpur, Malaysia, genotypic resistance testing was conducted among drug-naive HIV-1 patients attending the University Malaya Medical Center (UMMC) between July 2003 and June 2004. Reverse transcriptase (RT) and protease genes of plasma virions were sequenced from 100 individuals. The ...

Drug resistance is a crucial obstacle to achieve satisfactory chemotherapeutic effects. Numerous studies have shown that the PI3K/Akt signaling pathway plays significant role in various processes of cellular events and tumor progression, while few focused on drug endothelial cells. The present study aims explore relationship anticancer drugs human microvessel cells (HMEC-1). We established stab...

SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for global pandemic of COVID-19 disease. The Spike (S) protein attaches to host lung epithelial cells through cell surface receptor ACE2, a process dependent on proteases including TMPRSS2. Here, we identified small molecules that can reduce expression TMPRSS2 using 2,700 FDA-approved or current clinical trial compounds. Among the...

Vinca alkaloids are used widely in the treatment of both childhood and adult cancers. Their cellular target is the beta-tubulin subunit of alpha/beta-tubulin heterodimers, and they act to inhibit cell division by disrupting microtubule dynamics. Despite the effectiveness of these agents, drug resistance is a major clinical problem. To identify the underlying mechanisms behind vinca alkaloid res...

tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...

background: nowadays, nosocomial infection with multidrug-resistant acinetobacter is an important problem in the world, which is facing wide spectrum antibiotics and hence has become resistant. m aterials and methods: in this study, positive cultures of acinetobacter from one hundred clinical samples in seven hospitals from tehran during 2012-2013 were collected for checking antibiotic suscepti...