objective: to evaluate the effect of niprd-am1 on cyp3a4 in order to generate clinically significant data for its safe and efficacious use. materials and methods: niprd-am1 is a phytomedicine developed from aqueous root extracts of nauclea latifolia smith (rubiaceae) for the treatment of uncomplicated malaria. the effect of niprd-am1 on cyp3a4 was measured with and without the addition of niprd...

terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

During the last decade, the application of pharmacokinetic and pharmacodynamic modeling techniques has become an increasingly important aspect of contemporary clinical psychopharmacology (1–5). These techniques have been applied during the process of development of new drug entities as well as for the improved understanding of the clinical actions of drugs that are already marketed. Techniques ...