An enormous number of drugs are introduced to the market every year and practically it is not feasible to avoid potential drug interactions. These drug interactions can lead to altered systemic exposure, resulting in disparities in drug response of the other co-administered drugs. Additionally, associated ingestion of dietary supplements, citrus fruit/juice could also change systemic exposure o...

This paper investigates how incentives of network operators to deviate from neutrality may create social costs or benefits in different market structures. The deviation from network neutrality is a general form of discrimination based on charging different prices for non-affiliated content and application providers. In this paper, deviation from network neutrality is formulated as a form of ver...

The market enthusiasm generated around investment in CRM technology is in stark contrast to the naysaying by many academic and business commentators. This raises an important research question concerning the extent to which companies should continue to invest in building a CRM capability. Drawing on field interviews and a survey of senior executives, the results reveal that a superior CRM capab...

We examine using the Stochastic Grid Bundling Method (SGBM) to price a Bermudan swaption driven by a one-factor LIBOR Market Model (LMM). Using a wellknown approximation formula from the finance literature, we implement SGBM with one basis function and show that it is around six times faster than the equivalent Longstaff–Schwartz method. The two methods agree in price to one basis point, and th...

The paper presents recent developments in Morfeusz – a morphological analyser for Polish. The program, being already a fundamental resource for processing Polish, has been reimplemented with some important changes in the tagset, some new options, added information on proper names, and ability to perform simple prefix derivation. The present version of Morfeusz (including its dictionaries) is ma...

In this paper we set up a model of interacting drug epidemics by taking the ”direct-product” of variations on a one-dimensional optimal control model that exhibits a so-called DNSS or Skiba threshold. Such a threshold reflects in drug policy the well-established paradigm of ”eradication vs. accommodation”; that is, depending on the initial state, stabilizing a drug market at either a low or a h...

BACKGROUND The successful introduction of new drugs into low- and middle-income countries requires an understanding of the existing market size and market dynamics for the therapeutic area of interest. The drug markets in these countries are, however, less well understood than those in high-income countries. METHODS The global market for tuberculosis (TB) drugs was estimated by studying in de...

notwithstanding a century of prohibition, marijuana is the most widely used illicit substance in canada. due to the growing public acceptance of recreational marijuana use and ineffectiveness of the existing control system in canada, the issue surrounding legalizing this illicit drug has received considerable public and political attentions in recent years. consequently, the newly elected liber...

The Food and Drug Administration (FDA) provides a barrier to market entry and use of unproven and unsafe products. For prescription drugs, the FDA approval process requires substantial evidence of efficacy and safety for specific clinical situations. Although approval is indication-specific, the FDA has a limited role once a drug is on the market. Recent draft guidelines covering manufacturers'...

Understanding the history of the development of diagnostic criteria for ADHD, the parallel growth of the ADHD drug market, and factors that improve the symptoms of ADHD provides insight into alternative approaches to treatment and the potential for prevention. This chapter sheds light on the rise of ADHD as a diagnostic disorder, and highlights the growth of the ADHD drug market and associated ...