Dolutegravir is neither an inducer nor inhibitor of metabolising enzymes, and it therefore has a low propensity to act as perpetrator drug-drug interactions. Clinically significant decreases in dolutegravir exposure occur when co-administered with strong inducers (e.g. rifampicin, efavirenz) drug enzymes efflux transporters for which substrate – this can be overcome by increasing the dose from ...

objective: erectile dysfunction affects quality of life and is a common dysfunction in drug abusers. the aim of this study was to evaluate the frequency of erectile dysfunction in drug abusers on methadone maintenance therapy to reduce this drug side effect in the future studies . methods: this cross-sectional study was conducted with two hundred addicted individuals on methadone maintenance th...

objectives in this study, we aimed to determine the prevalence of the species of campylobacter. jejuni in zahedan, a major city in southeastern iran. patients and methods fecal samples from 164 patients with acute diarrhea from zahedan hospitals were collected from 2011 to 2013. then the samples were streaked onto a campylobacter selective agar containing supplement and 7% defibrinated sheep bl...

cockroaches were collected from hospitals, houses and poultry sheds in various parts of isfahan (iran) and identified to species. in total, seven species of cockroaches in seven genera were identified: blatta lateralis, polyphaga aegyptiaca, arenivaga roseni and parcoblatta spp. three species periplaneta americana, blattella germanica and supella longipalpa (blattidae and blattellidae) were mor...

the emergence of multi-drug resistant strains of pseudomonas aeruginosa has complicated treatment decision and may lead to treatment failures. in this study, we describe the trends of drug-resistant p. aeruginosa isolated in blood cultures from patients detected in a tertiary teaching hospital and evaluated the prevalence of resistance to amikacin, ampicillin, carbeni- cillin, cefixime, cefotax...

optimal reduction in blood pressure with antihypertensive agents helps to prevent microvascular and macrovascular complications of diabetes. the objective of the study was to evaluate the current utilization pattern of antihypertensive medications among patients with diabetes and coexistent hypertension as per the jnc seventh report guidelines. a cross-sectional survey was conducted among patie...

postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. the aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. this double blind randomized clinical trial was performed on full term pregnan...

pseudomonas aeruginosa is one of the most important pathogens that causes nosocomial infections and shows high level of antibiotic resistance. integrons are one of the transposable elements in bacteria and their role in antibiotic resistance has been well demonstrated. the aim of this study was a molecular characterization of the integron genes and the determination of the resistance or sensiti...

sepsis is a systemic inflammatory response to infection. sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. pathogenesis is extremely complex. in recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. sepsis damages the structure and function of mitochondria,conversely, mito...

background: multi drug resistant (mdr) pseudomonas and acinetobacter species are defined as resistant to at least three classes of antibiotics. most studies have demonstrated that mdr gram negative infections convey increased mortality and morbidity. case: an 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (tbsa). discussion: ...