In this paper we present a developmental framework to carry out goal-oriented learning in a low-dimensional space. The framework uses two stages of learning: one to synthesise a set of motor synergies and reduce the dimensionality of the control space in an unsupervised manner, and another to carry out supervised learning in the reduced control space. We test our framework in a reaching task ca...

This paper shows that Error-Driven Constraint Demotion (EDCD), an errordriven learning algorithm proposed by Tesar (1995) for Prince and Smolensky’s (1993) version of Optimality Theory, can fail to converge to a totally ranked hierarchy of constraints, unlike the earlier non-error-driven learning algorithms proposed by Tesar and Smolensky (1993). The cause of the problem is found in Tesar’s use...

Abstract Deep reinforcement learning methods have achieved significant successes in complex decision-making problems. In fact, they traditionally rely on well-designed extrinsic rewards, which limits their applicability to many real-world tasks where rewards are naturally sparse. While cloning behaviors provided by an expert is a promising approach the exploration problem, from fixed set of dem...

Software systems that are successfully deployed and used seem to always have a longer lifetime than was originally expected. It is also common knowledge that the cost of maintaining and evolving those systems during that lifetime dwarf the initial cost of creating the system. This makes support for self-management in the legacy software arena all that much more important. We are building an inf...

Lambda transducing phage gamma 16-2 carries the genes envA, ftsZ, ftsA, ddl, and murC and directs the synthesis of six unique proteins in ultraviolet-irradiated cells. Various derivatives of gamma 16-2 carrying smaller segments of the bacterial deoxyribonucleic acid have also been analyzed for their capacity to direct protein synthesis in ultraviolet-irradiated cells. These results, in combinat...

The Standard for the Exchange of Earthquake Data (SEED) is a commonly used file format in the seismology field. Steim1 and Steim2 compression schemes, i.e. lossless data compressions, are used in SEED format and are written in Data Description Language (DDL), which has computational limitations making it difficult to implement many standard compression algorithms. Steim1 and Steim2 are fixed co...

A dominant mutation of the gene encoding the POU4F3 transcription factor underlies human non-syndromic progressive hearing loss DFNA15. Using oligonucleotide microarrays to generate expression profiles of inner ears of Pou4f3(ddl/ddl) mutant and wild-type mice, we have identified and validated Lhx3, a LIM domain transcription factor, as an in vivo target gene regulated by Pou4f3. Lhx3 is a hair...

In the present work, the knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, inhibitors of n...

This article compares Defeasible Description Logics (DDL) and Topological Approach to reason on Ontologies with exceptions. DDL is integration between Description Logics and Defeasible Logics to deal with monotonic and non-monotonic parts of the knowledge bases respectively. Topological approach tries to reason on inconsistent knowledge bases using the conventional topological operators e.g., i...

A gene coding for D-alanine:D-alanine (D-Ala-D-Ala) ligase (ADP forming) (EC 6.3.2.4) activity has been isolated from a lambda library of Salmonella typhimurium DNA. Insertion mutations in the gene indicate that the gene is not essential for growth of the bacterium. The encoded enzyme was purified from an overproducing strain of S. typhimurium. D-Ala-D-Ala ligase is a protein of 39,271 molecula...