Increased trait impulsivity is a core element in several mental disorders. Given the durable and consistent nature of impulsivity, studies have explored its relation to stable biological measures. Variation catecholaminergic neurotransmission by genetic variants could be one these substrates. Here, 905 participants European-ancestry completed Barratt Impulsiveness Scale–11 were genotyped three ...

The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinf...

Human behavioral phenotypes are the result of complex interactions between genotype and the environment. Still, much remains unknown about the gene X environmental basis to adolescent delinquent involvement. Using data from the National Longitudinal Study of Adolescent Health, we examine whether a polymorphism in the dopamine D2 receptor (DRD2) gene interacts with religiosity to predict variati...

We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/...

AIM: To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization (CNV) in high myopia mice. METHODS: The C57BL/6J mice were deprived the right for 4wk, and was diagnosed optometry, diopter less than -6.00 D, CNV 532 nm laser. changes D1 receptor (DRD1), D2 (DRD2), vascular endothelial growth factor A (VEGFA) detected Western blot te...

Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the...

Although educational attainment has been found to be moderately heritable, research has yet to explore candidate genes for it. Drawing on data from the National Longitudinal Study of Adolescent Health, in the current study, we examined the association between polymorphisms in three dopaminergic genes (DAT1, DRD2, and DRD4), a dopamine index, and educational attainment. Statistically significant...

Deep brain stimulation targeting the subthalamic nucleus (STN-DBS) is an effective surgical treatment for the motor symptoms of Parkinson's disease (PD), the precise neuronal mechanisms of which both at molecular and network levels remain a topic of debate. Here we employ two transgenic mouse lines, combining translating ribosomal affinity purification (TRAP) with bacterial artificial chromosom...

BACKGROUND Among adolescent novice smokers, craving is often the first, and is the most reported, symptom of nicotine dependence. Until now, little has been known about the development of craving symptoms in novice smokers. The aim of this study was to identify specific genetic (i.e., DRD2 Taq1A, DRD4 48 bp VNTR, and OPRM1 A118G polymorphisms) and environmental mechanisms that underlie the emer...

In recent years, a possible role of the dopamine D2 receptor (DRD2) locus has been reported in various fields like the etiology of alcoholism, neuropsychiatric disorders, etc. Therefore, it has been the focus of considerable attention. DNA analysis has made it easier to study haplotypes, arrays of alleles at closely linked loci along the chromosome. These regions are short enough to show little...