نتایج جستجو برای: doxorubicin hydrochloride
تعداد نتایج: 73533 فیلتر نتایج به سال:
Cancer is the second leading cause of death in the United States and has become a health problem worldwide. The reported incidence of new cancer cases is estimated at 19.3 million, with a mortality rate of 10 million in the world in 2020. There are several therapeutic approaches for cancer, including chemotherapy. Chemotherapy is consuming anti-neoplastic drugs, alone or in combination. However...
Background and purpose: Incidence of breast cancer is increasing day by day. Scientists are interested in the effects of inhibition of breast cancer cell on treatment of this cancer. The aim of this study was to determine IC50 of doxorubicin in 24 hours on cell lines MCF-7 and MDA-MB-231 and the expression of heat shock protein HSP90α as a factor in the cell before and after 24 hours expo...
Introduction: Taxanes have emerged as one of the most active agents in the treatment of patients with breast cancer. Nevertheless, questions remain with regard to their toxicity profiles. This study aimed to compare prevalence and severity of adverse effects of two chemotherapy regimens including taxanes (docetaxel or paclitaxel) in breast cancer patients. Materials and Methods: Fifty patients ...
Doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. Dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. Here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in Iran at this time. Keywords: Pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, Iran.
Introduction: It has been reported that doxorubicin can cause liver damage; however, exercise and crocin consumption can improve antioxidant defense.The aim of the present study was to investigate the antioxidant effect of continuous training with crocin consumption on the liver tissue of doxorubicin-poisoned rats. Methods: In this experimental...
Introduction: Cancer is one of the most harmful disease throughout the world. Doxorubicin is an anti-cancer agent, used in the treatment of various types of the cancer such as bone cancer. There are several adverse effects related to clinical usage of Doxorubicin for long time. The present study aimed to investigate the reducing side effects and enhancing the therapeutic effect by liposomal car...
doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in iran at this time. keywords: pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, iran.
objective(s):the use of doxorubicin (dox) is limited by its dose-dependent cardio toxicity in which reactive oxygen species (ros) play an important role in the pathological process. the aim of this study was to evaluate the protective effect of three medicinal plants, nigella sativa (n), glycyrrhiza glabra (g) and zingiber officinale (z), and their combination (ngz), against dox-induced apoptos...
objective: doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose)exhibits potent antioxidant activity. so, in this study, we explored the protective effect...
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