Ran’s downhill slide during mitosis H asegawa et al. clarify the role of RanGTP in the formation of the mitotic spindle. Because RanGTP is prevalent in the cell, its job during spindle assembly has been difficult to nail down. One possibility is that RanGTP promotes construction of the spindle by liberating spindle assembly factors from the importins that carry them. Previous studies of Xenopus...

we report 11 year old male child, a case of acquired aplastic anemia as a complication of disseminated tuberculosis with acute onset, rapid downhill course and refractory to both antitubercular drugs as well as immunosuppressive drugs.

Compressed Natural Gas (CNG) is an affordable fuel with a higher octane number. However, older CNG kits without electronic controls have the potential to supply more when driving downhill due vacuum in intake manifold. Therefore, this article presents development of control system that accommodates road inclination angles improve efficiency. Machine learning involved work process engine speed, ...

Geckos employ their adhesive system when moving up an incline, but the directionality of the system may limit function on downhill surfaces. Here, we use a generalist gecko to test whether limb modulation occurs on downhill slopes to allow geckos to take advantage of their adhesive system. We examined three-dimensional limb kinematics for geckos moving up and down a 45° slope. Remarkably, the h...

PURPOSE The purpose of this study was to investigate the effect of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis. METHODS Thirteen moderately trained male subjects performed three 40 min treadmill runs at ~70% VO2max on separate days: a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately ...

Here, we studied muscle-specific and muscle-related miRNAs in plasma of exercising humans. Our aim was to determine whether they are affected by eccentric and/or concentric exercise modes and could be biomarkers of muscle injuries or possible signaling molecules. On two separate days, nine healthy subjects randomly performed two 30-min walking exercises, one downhill (high eccentric component) ...

Results: The overall injury distribution was valgus–external rotation (32.9%), phantom foot (22.5%), hyperextension (19.0%), boot induced (7.8%), collision (2.2%), and other (15.6%). The phantom foot mechanism was most common in ages 30 to 40 years (36.3% of all injuries within this mechanism; P < .01). Children and adults showed no significant difference in distribution of injury mechanism. Of...

PURPOSE This study aimed to quantify the intensity profile of elite downhill mountain bike races during competitions. METHODS Seventeen male downhill racers (22 ± 5 y; 185.1 ± 5.3 cm; 68.0 ± 3.9 kg; VO2peak: 59.4 ± 4.1 mL·min·kg-1) participated in the International German Downhill Championships in 2010. The racers' peak oxygen uptake and heart rate (HR) at 2 and 4 mmol·L-1 blood lactate (HR2 ...

BACKGROUND Downhill skiing is part of active life style in many residents of Alpine regions. However, only very little information is available whether downhill skiing on a regular basis is associated with a healthier life style resulting in the reduction of major risk factors for cardiovascular diseases and memory deficits when compared to the general population. Thus, the aim of the study was...