High risk human papillomaviruses (HR-HPVs) are associated with increased risk of normal cervical cells developing to dysplasia and cervical carcinoma. Therefore, HR-HPV DNA testing can predict an endpoint of cervical carcinogenesis that is earlier than the development of cervical abnormalities. Not only the sensitivity of methods but also the amount of HPV DNA are very important and might be pa...

The International Financial Reporting Standard (IFRS) 9 relates to the recognition of an entity’s financial asset/liability in its statement, and includes expected credit loss (ECL) framework for recognising impairment. quantification ECL is often broken down into three components, namely, probability default (PD), given (LGD), exposure at (EAD). IFRS standard requires that model accommodates i...

This paper describes the development and validation of a PCR array for studying chemical-induced effects on gene expression of selected endocrine pathways along the hypothalamic-pituitary-gonadal (HPG) axis of the small, oviparous fish, the Japanese medaka (Oryzias latipes). The Japanese medaka HPG-PCR array combines the quantitative performance of SYBR Green-based real-time PCR with the multip...

Abstract Introduction Peyronie’s Disease (PD) is a superficial fibrosing disorder characterized by inelastic fibrous plaques within the tunica albuginea. We previously performed high-resolution array comparative genomic hybridization analysis of DNA from men with both PD and Dupuytren’s (DD), yielding candidate genes, including NELL1, potential involvement in these conditions. NELL1 secreted gr...

Abstract Background Bone is the most common site of metastatic breast cancer, and it a leading cause cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in cancer. Methods Four mRNA datasets two lncRNA metastasis, lung metastasis liver cancer were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed mRNAs (DEmR...

Persistent high-risk human papillomavirus (HPV) infection is known to play an important role in the genesis of cervical cancer. Since new screening and prevention strategies, namely improved HPV testing and HPV vaccination have been aggressively promoted recently, it is crucial to investigate the HPV distribution in Malaysia in order to maximize their cost-effectiveness. This study was therefor...

Objective(s): MicroRNA-21 (miR21) is aberrantly elevated in rheumatoid arthritis (RA) patients, the significance of this microRNA in RA pathogenesis and treatment, however, has not been investigated. In this study, by using RA-derived fibroblast-like synoviocyte (FLS) cells as a model, we investigated the effect and corresponding mechanism of miR21 inhibition on FLSs invasion. Materials and Met...

Background and Objectives: Prostate cancer is the third most important cause of cancer deaths and one of the most common cancers in the world. Given the limited knowledge on environmental sounds and their effects, the important role of sounds is neglected in every culture across the world. The aim of this study was to investigate the impact of Quran recitation on prostate cancer cell line (PC-3...

Background: Varicocele (VCL) exerts its impact via enhancing inflammation and down-regulating testicular endocrine and antioxidant statuses. Celecoxib (CCB) is a non-steroidal anti-inflammatory drug (NSAID), which its effects based on the inhibition of cyclooxygenase (COX) enzymes. On the hand, silymarin (SMN) is known for its remarkable anti-oxidative impact. Therefore, present study was desig...