IMPORTANCE Purkinje cell cytoplasmic antibody type 1 (PCA-1)-IgG (or anti-Yo) is characteristically detected in women with gynecological or breast adenocarcinoma. We describe 2 unique scenarios occurring in 1 patient: PCA-1 paraneoplastic autoimmunity in a child, and a paraneoplastic neurological disorder in the context of Down syndrome. OBSERVATIONS A child with Down syndrome and a history o...

The Court report in 1976 laid down the classic blueprint for the organisation of children's mental health services.' Since then the priorities of health and other services have changed.2 Social services in some parts of the country have had to redirect social workers from child guidance to child protection work, often because of the major increase in reporting of child sexual abuse, and now als...

Excess female mortality during childhood is a distinct and unrelieved phenomenon in India, particularly in the two northern Indian states— Punjab and Haryana. This paper investigates the basic facts of sex differentials in child mortality in a very comprehensive manner using the three rounds of NFHS data sets from 1992 to 2006. More specifically, this paper examines the following three basic qu...

Chronic hyponatremia is very rare in children and is often seen in the setting of congestive heart failure or liver failure in adults. Here, we report an 8-year-old child with hypothalamic glioma who presented with severe hyponatremia. Initial management consisted of fluid restriction. This was very difficult for the child to follow and the child developed bizarre drinking habits requiring inte...

In May 2014, Evans et al1 reported that children with Down syndrome had lower rates of in-hospital death after cardiac surgery, compared with children without Down syndrome. Forty years ago, these results would have been unthinkable, as heart defects were not repaired in the majority of children with Down syndrome. However, as the field of cardiac surgery evolved, equal postoperative outcomes w...

There is a considerable and growing body of research investigating reading development in children with Down syndrome. However, there appears to be a common gap between the research evidence and instructional practices. It has been argued that teachers have insufficient information to enable them to implement effective literacy instruction with children with Down syndrome. This has important im...

Global Health 2035, the report of The Lancet Commission on Investing in Health, laid out a bold, highly ambitious framework for making rapid progress in improving global public health outcomes. It showed that with the right health investments, the international community could achieve a “grand convergence” in global health—a reduction in avertable infectious, maternal, and child deaths down to ...

Background: The social context is critical to children’s pain, and parents frequently form a major aspect of this context. We addressed several gaps in our understanding parent–child interactions during painful procedures identified intrapersonal contributions parental affective responses behaviors. used the pain empathy model framework examine venipuncture determine predictors parent distracti...