The neuropeptide somatostatin—a cyclic tetradecapeptide first isolated from ovine hypothalamus (1)—is the most widely distributed of the hypothalamic releasing hormones in the central nervous system and in the periphery, including the pancreas, gut, and pituitary. In the brain, somatostatin is believed to function as a neurotransmitter and neuromodulator (2). The effect of somatostatin in the p...