the pharmacokinetics of cefpirome after a single intravenous injection of 10 mg.kg -1 was studied in febrile cross-bred calves. e. coli endotoxin was administered intravenously to induce fever in calves. blood samples were collected at different time intervals and cefpirome levels were estimated by using microbiological assay technique. based on the plasma drug levels, the pharmacokinetic param...

the present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. the concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...

Human growth hormone (hGH) was administered to a group of osteoporotic patients at two dosage levels for a period of 6 mo each. The first dose employed was 2 units subcutaneously daily, and the second dose was 0.2W-3/4 units (where W is body weight expressed in kg) daily. There was no significant change in serum-cholesterol or triglyceride concentration despite the production of hyperglycemia a...

The most important limitation associated with the clinical use of cyclosporine is the narrow therapeutic range between its efficacy and toxicity. Effective treatment is further complicated by significant variation in intrapatient and interpatient pharmacokinetics of the drug. We describe a practical approach to pharmacokinetic analysis that does not interfere with the cyclosporine dosage regime...

Educational Objectives 1. Describe and calculate the dosage regimen of an aminoglycoside antibiotic for a patient with Gram negative sepsis. 2. Define the half-live of an aminoglycoside when given serum concentration time data. 3. Calculate the distribution volume of an aminoglycoside in a patient when given serum concentration time data. 4. Describe the physiologic variables which will change ...

The study was performed to determine the gestational age of preterm infants that requires amikacin therapeutic drug monitoring. A study was conducted in preterm infants on amikacin therapy with gestational age of 28 to 36 weeks. Therapeutic drug monitoring in preterm infants was performed based on their individual pharmacokinetics to avoid ototoxicity and nephrotoxicity. Its prerequisite, becau...

In patients battling cancer, many aspects of antimicrobial treatment become more complex, and standard antimicrobial regimens may be inadequate. Various pathophysiological changes in critically ill patients with cancer significantly affect the pharmacokinetics (PK) of antimicrobials. In an unacceptably high percentage of these patients, variability of relevant PK parameters results in inadequat...