For more than 70 years, the inhibitors of carbonic anhydrase (ICA) have been used in treatment glaucoma. Since 1995, topical forms ICA appeared among antiglaucoma drugs — dorzolamide, and since 1999 brinzolamide. The hypotensive efficacy safety gave rise to widespread use these various peculiarities mechanism action made it possible create on their basis effective fixed combinations, which allo...

PURPOSE To compare the intraocular pressure (IOP) lowering effect and safety of latanoprost, travoprost given every evening, and the fixed combination dorzolamide + timolol (DTFC) given twice daily in pseudoexfoliation glaucoma (PXG). METHODS This randomized, prospective, investigator-masked study has been conducted with 50 PXG patients. Patients were assigned to one of three groups: travopro...

Background: The aim of the study was to evaluate incidence xerophthalmia in individuals with glaucoma by administering a topical regimen antiglaucoma medication containing timolol and dorzolamide determine frequency ocular surface abnormalities among who are undergoing treatment medications. Methods: included total 75 participants both genders. A 50 units from 25 subjects under two or more agen...

OBJECTIVE To compare the safety and effectiveness of fixed-combination regimes (latanoprost- timolol and brinzolamide 1% compared to dorzolamide 1%/timolol and latanoprost) in open-angle glaucoma patients after switching from a combination of three topical antiglaucoma eye drops. METHODS We conducted an open, randomized 12-week multicenter prospective study. We randomly allocated 39 patients ...

PURPOSE A fluorophotometer designed to measure aqueous flow in murine eyes was tested with artificial fluorescein chambers and in live mice with different anesthesia regimens, aqueous flow suppressants, and an anterior chamber cannulation method. METHODS Two hours following topical fluorescein application, one group of CD-1 mice was anesthetized with ketamine/xylazine, 2,2,2-tribromoethanol, ...