SUMMARY The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled ...

Description Testing SNPs and SNP interactions with a genotypic TDT. This package furthermore contains functions for computing pairwise values of LD measures and for identifying LD blocks, as well as functions for setting up matched case pseudo-control genotype data for case-parent trios in order to run trio logic regression, for imputing missing genotypes in trios, for simulating case-parent tr...

We explore the behavior of two different statistical models, one based on the beta-binomial distribution and another based on simple unigrams. We show that tracking systems based on these models have complementary strengths and weaknesses: the Beta-Binomial system yields high precision at high decision threshold, but performance quickly degrades as the threshold drops; the Unigram system is not...

CHAPTER L GENERAL INTRODUCTION 1 [ntroduction I Dissertation Organization 4 References 5 CHAPTER 2. EVALUATION OF A SIMPLE METHOD FOR ESTIMATING SOLUTE TRANSPORT PAR.\>4ETERS: LABORATORY STUDIES 9 Abstract 9 [ntroduction 10 Materials and Methods 13 Results and Discussion 16 Conclusions 22 References 23 CHAPTER 3. A TIME DOMAIN REFLECTOMETRY METHOD TO MEASURE IMMOBILE WATER CONTENT AND MASS EXCH...

This paper examines the impact of a series of design changes to an online mathematics education course in terms of transactional distance between learner and teachers, pre-service education students’ attitudes towards mathematics, and their development of mathematical pedagogical knowledge. Transactional distance theory (TDT) was utilised to investigate and describe the interactions among cours...

This paper discusses the challenges that arise when large speech corpora receive an ever-broadening range of diverse and distinct annotations. Two case studies of this process are presented: the Switchboard Corpus of telephone conversations and the TDT2 corpus of broadcast news. Switchboard has undergone two independent transcriptions and various types of additional annotation, all carried out ...

We present a comparative study of lexical chain-based summarisation techniques. The aim of this paper is to highlight the effect of lexical chain scoring metrics and sentence extraction techniques on summary generation. We present our own lexical chain-based summarisation system and compare it to other chainbased summarisation systems. We also compare the chain scoring and extraction techniques...

This paper investigates the detection of named entity (NE) patterns by comparing the results of NE patterns resulting from a user analysis and a system analysis. Findings revealed that there are difference in NE patterns detected by system and user, something that may affect the performance of a TDT system based on NE detection.

Electrical cables of all types are subject to aggressive environments that can create defects or accelerate aging. Many application domains require diagnosis methods and tools. Among many methods, reflectometry has proven to be the best candidate and can be easily applied to the detection and localization of hard defects, while only requiring one access point to the wire. But soft defects are m...

This paper describes research into the development of techniques to build effective Topic Tracking systems. Topic tracking involves tracking a given news event in a stream of news stories i.e. finding all subsequent stories in the news stream that discuss the given event. This research has grown out of the Topic Detection and Tracking (TDT) initiative sponsored by DARPA. The paper describes the...