Chromosome replication in Escherichia coli is normally initiated at oriC, the origin of chromosome replication. E. coli cells possess at least three additional initiation systems for chromosome replication that are normally repressed but can be activated under certain specific conditions. These are termed the stable DNA replication systems. Inducible stable DNA replication (iSDR), which is acti...

It becomes now apparent that prokaryotic DNA replication takes place at specific intracellular locations. Early studies indicated that chromosomal DNA replication, as well as plasmid and viral DNA replication, occurs in close association with the bacterial membrane. Moreover, over the last several years, it has been shown that some replication proteins and specific DNA sequences are localized t...

DNA polymerase delta (Pol ? ) plays several essential roles in eukaryotic replication and repair. At the fork, Pol is responsible for synthesis processing of lagging-strand. origins, has been proposed to initiate leading-strand by extending first Okazaki fragment. Destabilizing mutations human subunits cause stress syndromic immunodeficiency. Analogously, reduced levels Saccharomyces cerevisiae...