Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation progression of cancer. The purpose this study was to retrospectively investigate expression mitochondrial tumor-suppressor DNA-repair proteins in patients oral squamous cell carcinoma (OSCC) evaluate relationship between their prognosis. We enrolled 197 OSCC who underwent surgical re...

Nucleotide sequence variation in mitochondrial DNA isolated from human leukemic cells has been analyzed by recombinant DNA techniques. Three hundred eighty-seven independent recombinant DNA clones, each containing one of three defined segments of mitochondrial DNA isolated from the neoplastic cells of four leukemic patients, were analyzed. Partial nucleotide sequence determination of the 387 cl...

TFAM (transcription factor A, mitochondrial) is a DNA-binding protein that activates transcription at the two major promoters of mitochondrial DNA (mtDNA)--the light strand promoter (LSP) and the heavy strand promoter 1 (HSP1). Equally important, it coats and packages the mitochondrial genome. TFAM has been shown to impose a U-turn on LSP DNA; however, whether this distortion is relevant at oth...

Objective(s) The mitochondrial defects in Friedreich's ataxia have been reported in many researches. Mitochondrial DNA is one of the candidates for defects in mitochondrion, and complex I is the first and one of the largest catalytic complexes of oxidative phosphorylation (OXPHOS) system. Materials and Methods We searched the mitochondrial ND4L gene for mutations by TTGE and sequencing on 30...

These studies report the isolation of a DNA polymerase from rat liver mitochondria. The enzyme has been purified 22-fold by differential ultracentrifugation, ammonium sulfate precipitation, and column chromatography on DEAEcellulose. The partially purified enzyme manifests all of the requirements shown by the known DNA polymerases of mammalian nuclei and bacteria. The enzyme has an optimal pH o...

The effect of thyroid hormone on the turnover of mitochondrial DNA and protein was studied in rat heart and liver. Changes in turnover were observed in both thyroidectomized and normal rats following administration of thyroid hormone. In heart and liver the turnover of mitochondrial DNA and protein was slower in thyroidectomized rats than in normal rats. The turnover of mitochondrial DNA and pr...

Haplotypes and haplogroups are linked sets of common DNA variants, acting as susceptibility or protective factors to complex disorders. Growing evidence suggests that dysfunction of mitochondrial bioenergetics contributes to the schizophrenia phenotype. We studied mitochondrial DNA haplogroups in schizophrenia patients. Since mitochondria are inherited from the mothers, we used healthy fathers ...

Nuclear mitochondrial-like sequences (numts) are copies of mitochondrial DNA that have migrated to the genomic DNA. We present the first characterization of numts in ants, these numts being homologues to a mitochondrial DNA fragment containing loci the 3' portion of the cytochrome oxidase I gene, an intergenic spacer, the tRNA leucine gene and the 5' portion of the cytochrome oxidase II gene. A...