The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the D...

Objective: To evaluate low-molecular-weight (LMW) DNA as possible prognostic biomarker in acute ischemic and hemorrhagic stroke. Methods:  LMW DNA samples were isolated from plasma and cerebrospinal fluid by phenol deproteinization, analyzed by gradient polyacrylamide electrophoresis and quantified by spectrophotometry. Results: Two common types of the stroke, ischemic and hemorrhagic, differ...

objective: to assess relative biological effectiveness (rbe) of 131i radiation relative to 60co gamma rays in glioblastoma spheroid cells. materials and methods: in this experimental study, glioblastoma spheroid cells were exposed to 131i radiation and 60co gamma rays. radiation induced dna damage was evaluated by alkaline comet assay. samples of spheroid cells were treated by radiation from 13...

Chromatin dynamics modulate DNA repair factor accessibility throughout the DNA damage response. The spatiotemporal scale upon which these dynamics occur render them invisible to live cell imaging. Here we present a believed novel assay to monitor the in vivo structural rearrangements of chromatin during DNA repair. By pair correlation analysis of EGFP molecular flow into chromatin before and af...

Kousuke Kasahara, Hidemasa Goto, Masato Enomoto, Yasuko Tomono, Tohru Kiyono and Masaki Inagaki* Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan, Department of Cellular Oncology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan, Division of Molecular and Cell Biology, Shigei Medical Research Institute, Okayama, Okayama, Japan and Virolog...

Recent evidence reveals an unexpected role for the linker histone H1.2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak.

the present study aimed to evaluate the antimicrobial activity of a hetroalkyl oximec synthetic compoundderivative (benzophenone o-4-bromoethyl oxime) against two gram positive and three gram negative bacteria.the antibacterial characteristic of this compound was shown using the circular zone diameter of bacterial growthinhibition by disk-diffusion method. in addition, the random amplified poly...

BACKGROUND AND OBJECTIVES: The eutrophication process is increased by anthropogenic or aquaculture facilities in marine ecosystems. DNA damage biomarkers for fish species detect genotoxic parameters for ecological risk assessment. The aim of the present study was to determine genotoxic potential induced by marine cage culture in Iskenderun Bay on gilthead sea bream (Sparus ...

Malathion (S-(1, 2-dicarboethoxyethyl) O, O-dimethyl phosphorodithioate) is one of the organophosphate pesticides comprehensively used in agriculture fields throughout the world. In spite of widely used, little information are available about DNA damage in aquatic organisms. Therefore, the present study carried out to investigation of DNA damage induced by malathion in Cyprinus carpio (Pisces: ...

Objective: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F.szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes. Materials and Methods: Human lymphocyt...