A key circuit in the response of cells to damage is the p53-mdm2 feedback loop. This circuit shows sustained, noisy oscillations in individual human cells following DNA breaks. Here, we apply an engineering approach known as systems identification to quantify the in vivo interactions in the circuit on the basis of accurate measurements of its power spectrum. We obtained oscillation time courses...

The vision for graphene and other two-dimensional electronics is the direct production of nanoelectronic circuits and barrier materials from a single precursor sheet. DNA origami and single-stranded tiles are powerful methods to encode complex shapes within a DNA sequence, but their translation to patterning other nanomaterials has been limited. Here we develop a metallized DNA nanolithography ...

The realization of artificial biochemical reaction networks with unique functionality is one of the main challenges for the development of synthetic biology. Due to the reduced number of components, biochemical circuits constructed in vitro promise to be more amenable to systematic design and quantitative assessment than circuits embedded within living organisms. To make good on that promise, e...

the purpose of this study was to evaluate the effect of short time circuit-resistance exercise with difference intensities on ghi/igf-i growth axis in healthy male students. for this purpose, 27 male students with mean and standard deviation of age 21.40±1.78 yr, height 172±0.45 cm, weight 68.85±5.39 kg were selected and randomly divided into three resistance exercise groups (each group, 9 subj...

It has only recently been discovered that naturally prevailing microorganisms have a notable role in flotation addition to chemical process parameters and overall water quality. This study’s aim was assess the microbial communities relation chemistry zinc copper mineral plant. Due limitations of cultivation-based methods detect fraction total diversity, DNA-based were utilised. However, it DNA ...

Various synthesis methods have been proposed in the literature for reversible and quantum logic circuits. However, there are few algorithms to optimize an existing circuit with multiple constraints simultaneously. In this paper, some heuristics in genetic algorithms (GA) to optimize a given circuit in terms of quantum cost, number of gates, location of garbage outputs, and delay, are proposed. ...

In this paper multi objective optimization problem for partitioning process of VLSI circuit optimization is solved using IPO algorithm. The methodology used in this paper is based upon the dynamic of sliding motion along a frictionless inclined plane. In this work, modules and elements of the circuit are divided into two smaller parts (components) in order to minimize the cutsize and area imbal...