We present a new locality sensitive hashing (LSH) algorithm for c-approximate nearest neighbor search in `p with 1 < p < 2. For a database of n points in `p, we achieve O(dn) query time and O(dn + n1+ρ) space, where ρ ≤ O((ln c)2/cp). This improves upon the previous best upper bound ρ ≤ 1/c by Datar et al. (SOCG 2004), and is close to the lower bound ρ ≥ 1/c by O’Donnell, Wu and Zhou (ITCS 2011...

Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients. The etiology of DN loss in sporadic PD is unknown, although it is hypothesized that aberrant protein aggregation and cellular oxidative stress may promote DN degeneration. Homozygous mutations in DJ-1 were recently describe...

It is widely appreciated that macroand microvascular complications, rather than hyperglycemia per se, are major contributors to morbidity and mortality in diabetes. In this issue of Diabetes, Williams et al. (1) report the results of a meta-analysis of genetic data from three moderately sized studies of patients with type 1 diabetes (T1D) and nephropathy. This report illustrates several challen...

The intrathymic transfer of semiallogeneic CD4/CD8 double-negative (DN) thymocyte stem cells into irradiated host mice resulted in a transient state of chimerism in adoptive host thymus, spleen, and lymph nodes. Host-derived T cells, isolated from the thymus and periphery of the chimeric mice, were found to be specifically nonresponsive to the MHC antigens of the semiallogeneic DN donor in cyto...

Abstract Background and Aims Diabetic nephropathy (DN), which is one of the most common systemic microvascular complications diabetes mellitus, extremely harmful to patients’ health. There were some studies had shown that disturbance lipid metabolism was connected with progression DN. Therefore, purpose our study find metabolism-related hub genes in DN provide a better reference for diagnosis M...

BACKGROUND Resistin-like molecule beta (RELM-β) has been reported to be associated with diabetic nephropathy (DN). However, the role of RELM-β in DN is poorly understood. This study was conducted to delineate the underlying mechanisms of action and to investigate the role of RELM-β in the primitive development of DN via MAPK signaling pathways. MATERIAL AND METHODS Lentivirus-mediated vectors a...

The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces pre-B-cell transformation. Signals emanating from the SH2 domain of the protein are required for transformation, and several proteins bind this region of v-Abl. One such protein is the adaptor molecule Shc, a protein that complexes with Grb2/Sos and facilitates Ras activation, an event associated with Ab...