Insulin like growth factor 2 (IGF2) is a crucial imprinting gene which prompting placenta development and fetal growth. It demonstrates parent-of-origin-specific allelic expression that is epigenetically regulated by differential methylation of IGF2/H19 DMR. We aim to explore if abnormal IGF2 imprinting status that regulated by altered DNA methylation of IGF2/H19 DMR affects IGF2 expression lea...

Inflation creates both scalar (density) and tensor (gravity wave) metric perturbations. We find that the tensor mode contribution to the CMB anisotropy on large-angular scales can only exceed that of the scalar mode in models where the spectrum of perturbations deviates significantly from scale invariance (e.g., extended and power-law inflation models and extreme versions of chaotic inflation)....

The Prader–Willi/Angelman imprinted domain on human chromosome 15q11–q13 is regulated by an imprinting control center (IC) composed of a sequence around the SNRPN promoter (PWS-SRO) and a sequence located 35 kb upstream (AS-SRO). We have previously hypothesized that the primary imprint is established on AS-SRO, which then confers imprinting on PWS-SRO. Here we examine this hypothesis using a tr...

Dirichlet Multinomial Regression (DMR) and other supervised topic models can incorporate arbitrary document-level features to inform topic priors. However, their ability to model corpora are limited by the representation and selection of these features – a choice the topic modeler must make. Instead, we seek models that can learn the feature representations upon which to condition topic selecti...

The auditory system of humans and animals must process information from sounds that dynamically vary along multiple stimulus dimensions, including time, frequency, and intensity. Therefore, to understand neuronal mechanisms underlying acoustic processing in the central auditory pathway, it is essential to characterize how spectral and temporal acoustic dimensions are jointly processed by the br...

Expression of imprinted genes is classically associated with differential methylation of specific CpG-rich DNA regions (DMRs). The H19/IGF2 locus is considered a paradigm for epigenetic regulation. In mice, as in humans, the essential H19 DMR--target of the CTCF insulator--is located between the two genes. Here, we performed a pyrosequencing-based quantitative analysis of its CpG methylation in...

Epigenetic alterations in human cancers include global DNA hypomethylation,gene hypomethylation and promoter hypermethylation, and loss of imprinting (LOI) of the insulin-like growth factor-II gene (IGF2). A mechanism for LOI described previously is hypermethylation of a differentially methylated region (DMR) upstream of the H19 gene, allowing activation of the normally silent maternal allele o...

Long non-coding RNAs (lncRNAs), transcribed from the intergenic regions of animal genomes, play important roles in key biological processes. In mice, Zdbf2linc was recently identified as an lncRNA isoform of the paternally expressed imprinted Zdbf2 gene. The functional role of Zdbf2linc remains undefined, but it may control parent-of-origin-specific expression of protein-coding neighbors throug...

Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1-F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine disruptor compounds bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP...