In this paper, we propose new approaches for solving the usefulskew tree (UST) routing problem [17]: Clock routing subject to general skew constraints. The clock layout synthesis engine of our UST algorithms is based on the deferred-merge embedding (DME) paradigm for zero-skew tree [5; 11 and bounded-skew tree [8; 21 routings; hence, the names UST/DME and Greedy-UST/DME for our algorithms. They...

In this paper, we analyze the feasibility of indoor broadband service provisioning using secondary spectrum access to the 960-1215 MHz band, primarily allocated to the distance measuring equipment (DME) system for aeronautical navigation. We propose a practical secondary sharing scheme customized to the characteristics of the DME. Since the primary system performs a safety-of-life functionality...

PURPOSE To review the most important metabolic effects and clinical safety data of subthreshold micropulse diode laser (D-MPL) in diabetic macular edema (DME). METHODS Review of the literature about the mechanisms of action and role of D-MPL in DME. RESULTS The MPL treatment does not damage the retina and is selectively absorbed by the retinal pigment epithelium (RPE). MPL stimulates secret...

Diabetic macular edema (DME) remains an important cause of visual loss. Although anti-vascular endothelial growth factor (VEGF) agents are generally used as first-line treatments for patients with center-involving DME, there is an important role for corticosteroids as well. Corticosteroids may be especially useful in pseudophakic patients poorly responsive to anti-VEGF therapies, in patients wi...

Diabetic macular edema (DME) is a leading cause of blindness in the working population. Herein, we report the case of a patient with recurrent DME for about 6 years, uncontrolled by several medical and surgical treatments, that was successfully treated with a single sustained-release fluocinolone acetonide intravitreal implant in her right eye. The affected eye had presented a visual acuity of ...

Treatment of an alkaline earth metal (Ca, Sr, Ba) with 2,4,6-trimethylphenol (HOmes) at elevated temperatures in the presence of mercury under solvent-free conditions, followed by extraction of the reaction mixture with 1,2-dimethoxyethane (dme), afforded dinuclear alkaline earth aryloxo complexes [Ae2(Omes)4(dme)4] (Ae = Ca 1, Sr 3, Ba 6). Extraction of the Ca metal and HOmes reaction mixture ...

In Focus • THE JOURNAL OF CELL BIOLOGY H ikers and migrating embryonic cells need to know their location so they can eventually reach their destination. Laplante and Nilson (1) reveal that some epidermal cells in the Drosophila embryo fi nd out where they are from their neighbors. Although it looks almost ready to hatch, a late-stage Drosophila embryo still has a gaping hole in its back. The op...

The salt metathesis reaction between one equivalent of SmI2(THF)2 and two equivalents K(C5Me4H) in THF afforded single crystals the unusual, toluene-soluble, asymmetric bimetallic Sm(II)/Sm(II) complex, (C5Me4H)2SmII(μ-η3:η5-C5Me4H)SmII(C5Me4H)(THF)2, instead expected product, (C5Me4H)2SmII(THF)2. toluene-insoluble products this can be worked up 1,2-dimethoxyethane (DME) to provide X-ray qualit...

Introduction Diabetes is a major chronic disease that can lead to serious health problems and high healthcare costs without appropriate disease management and treatment. In the United States, the number of people diagnosed with diabetes and the cost for diabetes treatment has dramatically increased over time. To improve patients' self-management skills and clinical outcomes, diabetes management...

We present new VLA radio observations of a sample of dMe stars in X, U, K, and Q bands (from 8.4 to 43 GHz) obtained during an observing campaign in 1996 April-June. The aim of the project was to determine the spectral energy distributions of late-type dwarf flare stars to investigate the possible existence of an inversion of the spectrum slope at frequencies higher than 8 GHz. We also tried to...