Teichoic acids (TAs), and especially lipoteichoic acids (LTAs), are one of the main immunostimulatory components of pathogenic Gram-positive bacteria. Their contribution to the immunomodulatory properties of commensal bacteria and especially of lactic acid bacteria has not yet been investigated in detail. To evaluate the role of TAs in the interaction between lactic acid bacteria and the immune...

BACKGROUND Toxicity data from cancer trials are summarized into a single outcome, dose-limiting toxicity (DLT), which does not account for multiple lower grade toxic effects nor differentiates between toxicity types and gradations within DLT. METHODS Toxicity data were summarized into a toxicity burden score (TBS) using a weighted sum. The severity weights were estimated via regression using ...

The effect of using a "residualizing" iodine radiolabel, dilactitol-iodotyramine, for radioimmunolocalization of antibodies to tumors was investigated. This tracer is designed to be lysosomally trapped after catabolism of the labeled antibody. mAbs RS7 and RS11 were used for in vivo and in vitro studies on the uptake and retention of radioisotope into tumor cells. Both are murine IgG1 mAbs with...

The use of distributed data storage and management structures, such as Distributed Ledger Technologies (DLT), in the energy sector has gained great interest recent times. This opens up new possibilities e.g. microgrid management, aggregation resources, peer-to-peer trading, integration electromobility or proof-of-origin strategies. However, order to benefit from those possibilities, challenges ...

The objective of this study is to introduce a new use case under smart energy cyber-physical-social system (CPSS) that brings together the competence distributed ledger technology (DLT) and essence peer-to-peer local markets. This involves donation sharing DLT-based charity support financially-disadvantaged citizens in covering their residential requirements an anonymous effective manner, as me...

In this paper we analyze energy usage in divisible load processing. Divisible load theory (DLT) applies to computations which can be divided into parts of arbitrary sizes, and the parts can be independently processed in parallel. The shortest schedule for divisible load processing is determined by the speed of computation and communication. Energy usage for such a time-optimum schedule is analy...

The warp problems usually make the documents being hardly recognized. Specifically, when we copy a page of a thick book or bound document by digital photocopier, the resulted image is usually warped because of the thickness of the document. We focus on this problem and propose a fast method to restore the warped document image in this paper. The text rectangle area of the document is one of the...

This article outlines our participation in the Question Answering Track of the Text REtrieval Conference organised by the National Institute of Standards and Technology. This was our second year in the track and we hoped to improve our performance relative to 2002. In the next section we outline the general strategy we adopted, the changes relative to last year and the approaches taken to the t...

0018-9251/00/$10.00 @ 2000 IEEE Computing over distributed environments has attracted more and more research efforts, since: it leverages the existing hardware and software and outweighs the supercomputer on the flexibility and performance-price ratio. One of the primary issues in the area of distributed computing is on how to divide and schedule loads in order to achieve Ihe best performance i...

Using isogenic clinical bloodstream Staphylococcus aureus strains from a patient with relapsing endocarditis, we investigated the transcriptional profiles of the mprF and dlt genes in the context of cell-surface charge and daptomycin nonsusceptibility. As in prior studies, a point mutation within mprF was observed in the daptomycin-nonsusceptible strain. However, neither the transcriptional pro...