The present investigation was aimed at investigating the diuretic activity of Bixa orellana Linn. leaves. The dried leaf powder was subjected to successive Soxhlet extraction with petroleum ether, chloroform, ethyl acetate, methanol and water. Among these, petroleum ether, methanolic and aqueous extracts were investigated for diuretic activity in Wistar rats using standard methods. The diuretic...

The rate of secretion of the Malpighian tubules of Glossina austeni is controlled by a diuretic hormone. This hormone is present in the nervous tissue of the fly together with a degradative enzyme that can be activated by boiling. It is demonstrated that the Malpighian tubules are able to destroy the diuretic hormone; they may therefore participate in the control of diuresis. The diuretic hormo...

One hundred cases of hypertension were investigated and treated with Prazosin alone, Prazosin with a diuretic and Prazosin, Diuretic and a Beta-adrenergic blocker. They were followed up for two and more than two years. Prazosin was found to be very safe and effective antihypertensive drug either alone or in combination with a Diuretic, or Beta-adrcnergic blocker in various grades of hypertensio...

In patients with hypertension resistant to three or four drugs including a thiazide diuretic substitution of frusemide for the thiazide, or the addition of spironolactone, produced significant reductions in blood pressure and body weight. The response did not depend on the presence of overt fluid retention, renal impairment, or the use of antihypertensive drugs of high potency. Women had larger...