Inhibition of the growth of Lactobadlus casei with folic acid as the nutrilite is a general property of 2,4-diaminopyrimidines, 2-aminopyrimidines, and condensed systems containing these groupings (1). These compounds comprise a spectrum of inhibitors. At one end lie the simpler diaminopyrimidines which are competitive antagonists of folic acid (1, 2). The center may be represented by 2-aminopu...

The CoI2(PPh3)2/Zn system effectively catalyzes the [2 + 2 + 2] ene-diyne cycloaddition of 1,6-heptadiynes with allenes in a highly regio- and chemoselective fashion to yield substituted benzene derivatives in good to excellent yields.

A new strategy for Rh(I)-catalyzed [2+2+2] cycloadditions of 1,6-diynes with potassium (Z)-(2-bromovinyl)trifluoroborate as the third two-atom unit has been realized, which provides a facile entry to polysubstituented benzene derivatives.

microwave-assisted three component cyclocondensation reactions of aldehydes, amides and dienophiles in the presence of acetic anhydride and para-toluenesulfonic acid as a catalyst to afford the highly substituted cyclohexene derivatives, in relatively good yields after several minutes are reported.