The ?–?* transitions of disubstituted spiropentadiene become helical due to mixing its two perpendicular ?-systems. helicity is symmetry-protected and gives rise experimentally observable effects, such as optical activity.

Unprotected homoallylic alcohols can be directly converted to cis-2,6-disubstituted pyrans by palladium catalyzed B-alkyl Suzuki coupling and subsequent Michael addition.

Directed catalytic asymmetric hydroborations of 1,1-disubstituted alkenes afford γ-dioxaborato amides and esters in high enantiomeric purity (90-95% ee).

Catalytic reductive coupling processes have been developed in numerous contexts as a strategy for the regioand stereoselective installation of alkenes. The direct coupling of a polar p system with a relatively nonpolar p system is often a successful strategy for selectively accomplishing synthetically desirable heterocouplings while avoiding undesired homocoupling of either reagent. For example...

A series of diarylureas and diarylamides possessing pyrrolo[2,3-d]pyrimidine scaffold was designed and synthesized. The in vitro antiproliferative activities of a selected group of the target compounds against NCI-60 cell line panel were tested and compared with Sorafenib and Imatinib as reference compounds. Most of the compounds showed strong and broad-spectrum antiproliferative activities. Co...

A high yielding and modular approach to N,N'-disubstituted imidazolium salts is described, providing access to substitution patterns that are beyond the reach of established methodology.

1,3-Disubstituted-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazines were prepared through the ring-closure reactions of the aminobenzylnaphthols with substituted aryl- and heteroarylaldehydes.

Acanthus ilicifolius has long history of medicinal plant belong to the family Acanthaceae. In the present study, ethanolic extract of A. ilicifolius showed antitumour potential against HepG2 cell line induced hepatocarcinoma in mice. The phytochemical analysis were studied by using strandard methods. The heptocarcinoma mice were orally treated with extract of A.ilicifolius (500 mg/kg B.W). The ...

Abstract We report the application of Pd(II)-catalyzed, directing-group-aided C–H arylation/alkylation tactics to functionalize pyrene core, especially, relatively inaccessible C2 and K-region C10 positions core augmentation library derivatives with C1,C2- C1,C10-disubstituted motifs. The Pd(II)-catalyzed β-C–H C2-position pyrene-1-carboxamide possessing an 8-aminoquinoline directing group yiel...