We have used a novel model of genetically imparted endurance exercise capacity and metabolic health to study the genetic and environmental contributions to skeletal muscle glucose and lipid metabolism. We hypothesized that metabolic abnormalities associated with low intrinsic running capacity would be ameliorated by exercise training. Selective breeding for 22 generations resulted in rat models...

OBJECTIVE To determine whether a chronic low-glycemic index (LGI) diet, compared with a high-glycemic index (HGI) diet, has beneficial effects on plasma glucose control, lipid metabolism, total fat mass, and insulin resistance in type 2 diabetic patients. RESEARCH DESIGN AND METHODS Twelve type 2 diabetic men were randomly allocated to two periods of 4 weeks of an LGI or HGI carbohydrate diet...

GENETIC IRON OVERLOAD disorders are prevalent yet poorly understood. Over the past 3 years, the discoveries of the hereditary hemochromatosis gene and an intestinal iron transporter have significantly advanced our understanding of iron metabolism. Furthermore, they have suggested novel links between molecules involved in immune defense and iron homeostasis. These findings lay the foundation for...

BACKGROUND AND PURPOSE The purpose was to assess the prevalence of disorders of glucose metabolism and insulin resistance in Japanese ischemic stroke patients with no history of diabetes by performing 75-gram oral glucose tolerance test (OGTT). METHODS We recruited 427 ischemic stroke patients (atherothrombotic infarction, n=220; lacunar infarction, n=125; cardioembolic infarction, n=82). OGT...

Aim of the study was to explore impact apolipoprotein E ( APOE ) gene polymorphisms (GP) on gallstone disease (GSD) and type 2 diabetes mellitus (DM2) its role in lipid metabolism. APOE4 allele carriers had highest levels plasma bile cholesterol lowest acids than other alleles. In GSD a higher frequency (2.6 times compared control) found. risk reduced by 12 % APOE2 APOE3/3. Our 20-year research...

objective: the purpose of the present study was to examine the impact of menstrual cycle abnormalities among patients with polycystic ovary syndrome (pcos) on biochemical and anthropometric characteristics. materials and methods: we conducted a prospective observational study of patients 17-35 years of age with pcos that attended the department of gynecological endocrinology of our hospital. re...

The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [(11)C]DASB [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rh...

background and objectives: there is convincing evidence that subjects concomitantly affected by type 2 diabetes (t2d) and metabolic syndrome (mes) are at greater risk for cardiovascular disease (cvd). many metabolic derangements in t2d might be attributed to poor vitamin d status. the purpose of this study was to investigate the associations among vitamin d status, mes and glycemic status in su...

Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially pancreatic beta-cell function, is rarely investigated. Our current study mainly focused effects prenatal metabolism and beta- cell function aged By using mice their offspring as animal models, we found that treatment induced ...

Background: Diabetes Mellitus is a heterogeneous group of different metabolic disorders that are characterized by chronic increase of blood glucose, cardiovascular diseases, and proteins, lipids and carbohydrate metabolism disorder. Leptin, that is a marker of fat mass in the body, has an important role in the body total metabolism and glucose homeostasis. Aim: To investigate the effect of 12 w...