Numerous studies demonstrate that free glutamine can be added to commercially available crystalline amino acid-based preparations before their administration. Instability during heat sterilization and prolonged storage and limited solubility (35 g/L at 20°C) hamper the use of free glutamine in the routine clinical setting. Indeed, there are many well-controlled and valuable trials with free glu...

Doliculide belongs to a group of marine cyclodepsipeptides with interesting biological properties. Apart from halogenated dipeptide, polyketide fragment containing 5 stereogenic centers is the most eye-catching element. This building block can be synthesized in highly stereoselective fashion using only one key reaction: Matteson homologation. straightforward protocol allows for introduction wid...

Human immunodeficiency virus type 1 (HIV-1) strains having dipeptide insertions in the fingers subdomain and other drug resistance-related mutations scattered throughout their reverse transcriptase (RT)-coding region show high-level resistance to zidovudine (AZT) and other nucleoside analogues. Those phenotypic effects have been correlated with their increased ATP-dependent phosphorolytic activ...

Enhancement of depressed plasma concentrations of glutamine and arginine is associated with better clinical outcome. Supplementation of glutamine might be a way to provide the patient with glutamine, and also arginine, because glutamine provides the kidney with citrulline, from which the kidney produces arginine when plasma levels of arginine are low. The aim of the present study was to investi...

C3-symmetrical molecules are described which consists of a 1,3,5-benzenetricarboxamide core extended with dipeptide fragments bearing peripheral mesogenic groups. Small structural modifications in the dipeptide fragment have been performed to demonstrate their influence on the stability of the stacks and on the order within the self-assemblies formed. Seven C3-symmetrical discs have been invest...

To explore the feasibilityof targeting human tumor cells via their trans port systems, dipeptide uptake was Studied in the human fibrosarcoma cell line HT1OSOand the human fibroblast cell line IMR-90 by the use of hydrol ysis-resistant glycytsarcosine (Gly-Sar). The uptake of [†̃4CJGly-Sar into HT1OSOwas time dependent Kinetic analysis of the concentration depend ence ofthe initial rate of['4C...

Among three biologically active substrates of angiotensin-converting enzyme, enzyme-binding affinities increase and chloride ion rate enhancements decrease in the following order: angiotensin I (Asp-Arg-Val-TyrIle-His-Pro-Phe-His-Leu), bradykinin (Arg-Pro-ProGly-Phe-Ser-Pro-Phe-Arg), bradykinin-potentiating peptide 5, (<Glu-Lys-Trp-Ala-Pro). Qualitatively simil a r properties are observed among...