An Escherichia coli strain engineered for expression of the ribABGH genes of Bacillus subtilis was shown to produce 100 mg of the riboflavin precursor 6,7-dimethyl-8-ribityllumazine per liter of minimal medium. Growth of the recombinant strain in medium supplemented with [U-13C6]glucose and/or 15NH4Cl as single sources of carbon and/or nitrogen afforded 6,7-dimethyl-8-ribityllumazine universall...

Biogenic Sulfur Compounds, Gas Chromatography, Concrete Corrosion Pseudomonasßuorescens, Proteus vulgaris, and Serratia marcescens, members o f the microflora of soil and waste water, attacked methionine in the presence o f glucose. The sulfur o f m ethionine was released as methane thiol, dimethyl sulfide and dimethyl disulfide. The volatile sulfur com ­ pounds were qualitatively and quantitat...

Oxidative stress contributes to pathology associated with inflammatory brain disorders and therapies that upregulate antioxidant pathways may be neuroprotective in diseases such as multiple sclerosis. Dimethyl fumarate, a small molecule therapeutic for multiple sclerosis, activates cellular antioxidant signaling pathways and may promote myelin preservation. However, it is still unclear what mec...

A series of pyranopyrazoles, namely, 7-(2-aminoethyl)-3,4-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one (2), (Z)-3,4-dimethyl-1-(4-((4-nitrobenzylidene)amino)phenyl)pyrano[2,3-c]pyrazol-6(1H)-one (5), 1-(4-(3,4-dimethyl-6-oxopyrano[2,3-c]pyrazol-1(6H)-yl)phenyl)-3-(naphthalen-1-yl)urea (6), (Z)-ethyl 4-((3,4-dimethyl-6-oxo-1,6-dihydropyrano[2,3-c]pyrazol-5-yl)diazenyl)benzoate (8) and 3...

Biotransformation of nerol by larvae of the common cutworm (Spodoptera litura) was investigated. The resulting major metabolites were (2Z,6E)-1-hydroxy-3,7-dimethyl-2,6-octadien-8-oic acid and 8-hydroxynerol, and the minor metabolites were 9-hydroxynerol and (2Z,6E)-1-hydroxy-3,7-dimethyl-2,6-octadien-8-al. (2Z,6E)-1-Hydroxy-3,7-dimethyl-2,6-octadien-8-oic acid is a novel compound. The results ...

tow new compound of type [(chelate)2cu-oh-cu(chelate)2] x3.nh2o, where chelate=1,10-phenanthroline; x=cl¯(n=3.5) and chelate=4,4'-dimethyl-2,2'-bipyridine;  (n=5) have been synthesized and their properties investigated. the complexes show room temperature magnetic moment order of 1.0 b.m. per copper atom. the x-band esr spectrum of powdered samples at room temperature shows typical dm=1 transit...

The dimerization of acetoacetamide easily proceeds at room temperature in a dimethyl sulfoxide solution to afford 5-carbamoyl-4,6-dimethyl-2-pyridone.

The reaction of dimethyl acetylenedicarboxylate with OH-acid such as 2-naphthol in the presence of trimethyl or triphenyl phosphite under solvent-free conditions produce oxaphosphaphenanthrene derivatives in good yields. Also, the reaction of dimethyl acetylenedicarboxylate and trimethyl phosphite in the presence of 1-naphthol leads to succinate derivatives in excellent yields. Using triethyl p...