An efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as s...

An efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as s...

An efficient and simple procedure for the synthesis of 1,8-dioxo-octahydroxanthenes from the aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of boric acid [BO3H3 or B(OH)3] as an inexpensive and reusable catalyst is described. The salient features of this methodology are: the elimination of corrosive liquid acids, high yields, simple methodology, short reacti...

An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction cond...

Antigen-presenting cells (APC) are thought to play an important role in the pathogenesis of drug-induced immune reactions. Various pathological factors can activate APC and therefore influence the immune equilibrium. It is interesting that several diseases have been associated with an increased rate of drug allergy. The aim of this project was to evaluate the impact of such "danger signals" on ...

An efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short...

Melamine trisulfonic acid (MTSA) as an efficient heterogeneous catalyst has been used for the one-pot preparation of triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives by the three-component condensation reaction of urazoles or phthalhydrazide, dimedone or 1,3-cyclohexanedione, and aldehydes under solvent-free conditions in good to excellent yields ...

In this study, multi component Hantzsch reaction was carried out between various  Aromatic Aldehyde with Dimedone,Ethyl acetateand ammonium acetate to produce polyhydroquinolinederivatives under solvent-free conditions at 110oC by a (Zinc oxide  nanocatalyst) as effective Lewis acid. The remarkable advantages offered by this method compared with other methods are a green catalyst, simple work-u...

The condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including highyields, low reaction times, easy work up and little catalyst loading.

Zinc chloride silica gel-supported was found to be an efficient, inexpensive catalyst for the synthesis of 1,8-dioxodecahydroacridines via one-pot three-component condensation of aryl aldehydes, dimedone, andammonium acetate in high yields. The described novel synthetic method propose several advantages of safety, mild condition, short reaction times, high yields, simplicityand easy workup comp...