The GI tract is the most exposed organ to proteases, both in physiological and pathophysiological conditions. For digestive purposes, the lumen of the upper GI tract contains large amounts of pancreatic proteases, but studies have also demonstrated increased proteolytic activity into mucosal tissues (both in the upper and lower GI tract), associated with pathological conditions. This review aim...

Many gluten peptides elicit proliferative responses from T cells from Celiac Sprue patients, influencing the pathogenesis of this small intestinal disorder. These peptides are Pro- and Gln-rich in character, suggesting that resistance to proteolysis promotes their toxicity. To test this hypothesis, we analyzed the digestive resistance of a panel of alpha- and gamma-gliadin peptides believed to ...

Textural quality of fish and shellfish is the most important factor because it limits consumer acceptance as well as market price. The muscle softening or mushiness of fish and shellfish during storage or distribution in ice is generally occurred. This phenomenon is considered as the muscle protein degradation due to the proteolytic activity. The presence of active proteases in muscle and diges...

The Hessian fly, Mayetiola destructor, is a serious pest of wheat and an experimental organism for the study of gall midge-plant interactions. In addition to food digestion and detoxification, the gut of Hessian fly larvae is also an important interface for insect-host interactions. Analysis of the genes expressed in the Hessian fly larval gut will enhance our understanding of the overall gut p...

Natural products such as plant extracts and complex microbial secondary metabolites have recently attracted the attention of scientific world for their potential use as drugs for treating chronic diseases such as Type II diabetes. Non-Insulin-Dependent Diabetes Mellitus (NIDDM) or Type II diabetes has complicated basis and has various treatment options, each targeting different mechanism of act...

A total of 59 isolates of different Haemophilus spp., mostly from clinical specimens, was characterised, biotyped and examined for production of type 1 or type 2 IgA1 protease. IgA1 protease activity was not found in any isolate of a species with no or low virulence for man including H. parainfluenzae, H. haemolyticus, H. aphrophilus, H. paraphrophilus, H. segnis, H. paraphrohaemolyticus and H....

Hemorrhagic shock (HS) is associated with high mortality. A severe decrease in blood pressure causes the intestine, a major site of digestive enzymes, to become permeable - possibly releasing those enzymes into the circulation and peritoneal space, where they may in turn activate other enzymes, e.g. matrix metalloproteinases (MMPs). If uncontrolled, these enzymes may result in pathophysiologic ...

the aim of this study was to determine the inhibitory effects of feed ingredients on protease activities of argyrosomus regius larvae using in vitro techniques. a. regius larvae fed on a commercial feeding procedure were sampled thirteen times, during the sampling period (from 3 to 32 days after hatching (dah)). the differences observed in protease activities of meagre larvae during the samplin...

Nef is an important player for viral infectivity and AIDS progression, but the mechanisms involved are not completely understood. It was previously demonstrated that Nef interacts with GagPol through p6*-Protease region. Because p6* and Protease are involved in processing, we explored the effect of Nef on viral Protease activity and virion assembly. Using in vitro assays, we observed that Nef i...