Introduction: Retention of I-131 in the body of patients with differentiated thyroid carcinoma (DTC) has a direct effect on therapeutic outcome of radioiodine therapy. There are several factors that may influence retention time of radioiodine in the body of these patients. In this study we are going to assess effects of administered radioiodine activity, serum thyroid stimulati...

Differentiated thyroid cancer comprises papillary, mixed papillary-follicular and follicular adenocarcinomas. They are mostly hormone-sensitive and respond to thyroid-stimulating hormone (TSH) suppression. The standard treatment is total thyroidectomy, (131)I therapy and thyroid hormone suppression therapy. Adjuvant external radiotherapy is discussed controversially. Most authors recommend adju...

Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who present...

mlU/l. The symptoms of sensitive polyneuropathy manifested soon after introducing levothyroxine therapy. Fatigue, lack of concentration, forgetfulness, depression, and widespread neuropathic pain persisted more than 2 years in spite of levothyroxine replacement therapy (125 g levothyroxine daily) and TSH level of Dear Sir, Five months after radioactive iodine treatment for Graves’ hyperthyroidi...

There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be ...

Thyrotoxicosis has long been known to accelerate bone turnover and thus increase the risk for developing osteoporosis, especially in periand postmenopausal women. Increasingly sophisticated tests of thyroid function have indicated that minor degrees of hyperthyroidism are common in patients taking thyroxine (T4) therapy. Recent reports have suggested that women taking TSH-suppressive doses of T...

Volume 91, Number 6 www.aafp.org/afp American Family Physician 359 Primary hypothyroidism is defined as low levels of blood thyroid hormone due to destruction of the thyroid gland. This destruction is usually caused by autoimmunity or an intervention such as surgery, radioiodine, or radiation. • It can be classified as clinical (overt) when diagnosed by characteristic clinical features, raised ...

Thyroid diseases are common, and use of levothyroxine is increasing worldwide. We investigated the influence of gender, race and socioeconomic status on the diagnosis and treatment of thyroid disorders using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicenter cohort study of civil servants (35-74 years of age) from six Brazilian cities. Diagnosis of thyroid d...

Hashimoto’s thyroiditis can lead to depression, anxiety disorder, and sleep problems. However, this autoimmune disease has been reported be less related psychotic depression. The case applied our outpatient clinic with introversion, anhedonia, guilt thoughts. patient was admitted a preliminary diagnosis of TSH value found high in the patient’s hormone analysis. Afterward, treatment started acco...

FDG PET in Thyroid Cancer: Thyroxine or Not? For decades, highly specific functional imaging in thyroid cancer was associated with several disadvantages of hypothyroidism. To achieve an optimal radioiodine uptake in remnant tissue and in malignant thyroid cells, it was necessary to withdraw thyroid hormone medication to increase thyroidstimulating hormone (TSH) secretion to values .30 mIU/L, if...