BACKGROUND The study reviews the anticancer properties of natural isoflavones which occur in especially high concentration in soybeans. It considers the suitability of soybean products for clinical trials aiming to reduce the progression of breast cancer. METHODS Evidence is reviewed that plant isoflavones such as genistein show cytostatic activity against human mammary cancer cell lines in v...

Nutritional interventions are important alternatives for reducing the prevalence of many chronic diseases. Soy is a good source of protein that contains isoflavones, including genistein and daidzein, and may alter the risk of obesity, Type 2 diabetes, osteoporosis, cardiovascular disease, and reproductive cancers. We have shown previously in nonhuman primates that soy protein containing isoflav...

BACKGROUND Soy isoflavones are being evaluated as chemopreventive agents for breast and other cancers. OBJECTIVE The objective was to perform safety and pharmacokinetic studies of purified unconjugated isoflavone preparations containing genistein, daidzein, and glycitein in postmenopausal women. DESIGN Twenty-four healthy postmenopausal women ingested a single dose of 1 of 2 purified (from ...

We studied urinary riboflavin as an objective biomarker of compliance in clinical research using a simplified method amenable to high throughput analysis. Six healthy women not taking vitamin supplements ingested a study pill containing riboflavin (32 mg) as an inactive tracer and the soy isoflavones daidzin (0.243 mmole) and genistin (0.222 mmole) as active ingredients once daily for four days...

Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, accounting for 15% of all cancers in men worldwide. Asian populations consume soy foods as part of a regular diet, which may contribute to the lower PCa incidence observed in these countries. This meta-analysis provides a comprehensive updated analysis that builds on previously published meta-analyses, demonstrating that...

The soybean isoflavones, daidzein, genistein, and glycitein, were hypothesized to act as cholesterol-lowering components, separate from soy protein. Pure synthetic daidzein, genistein, or glycitein (0.9 mmol/kg diet) or a casein-based control diet was fed to groups of 10 female Golden Syrian hamsters for 4 weeks. Hamsters fed glycitein had significantly lower plasma total (by 15%) and non-HDL (...

Preliminary findings from multiple studies indicate that dietary intake of soy-derived isoflavones exert beneficial effects on the skin including defense against oxidant damage, stimulation collagen synthesis, and increased hydration. This study aims to investigate how oral supplementation a soy protein isolate with added (SPII) affects components photoaging such as facial wrinkles dyspigmentat...

The effect of dietary soy on cardiovascular disease risk factors has been a topic of intense scientific and public interest over the past 10 or more years—a topic that was brought to the forefront by Anderson’s 1995 meta-analysis that highlighted clinical studies from the previous 20 y (1). The originally reported magnitude of the hypocholesterolemic effect of soy protein (9.3% decrease in tota...

2 Background: Isoflavones and lignans (phytoestrogens) are dietary components with potential 3 anti-carcinogenic effects. Although the intake of isoflavones and lignans may affect breast 4 cancer treatment and prognosis – and associations may differ by menopausal status post5 diagnosis intake data are limited. 6 Objective: We aimed to describe post-diagnosis isoflavone and lignan intake in newl...

The reproductive hormone environment is an important influence upon spontaneous ovarian granulosa cell (GC) tumor development in genetically susceptible (SWR x SWXJ-9) F1 female mice: androgenic support during puberty stimulates tumorigenesis, while exposure to 17beta-estradiol (E(2)) suppresses tumor initiation. We sought to determine whether gonadotropic stimulation was sufficient to initiate...