Single crystal piezoelectric composite transducers including 75 MHz PC-MUT (piezoelectric composite micromachined ultrasound transducers), diced 10 MHz and 15 MHz 1-3 composite transducers were successfully demonstrated with broad bandwidth and high sensitivity. In this paper, the design, fabrication and characterization of composite transducers are reported. C-scan experiments for SiC ceramic ...

background dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. the chondrocyte is surrounded by a pericellular matrix (pcm), together forming the chondron. pcm has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...

Background: Hyaline cartilage defects exhibit a major challenge in the field of orthopedic surgery owing to its limited repair capacity. On the other hand, mesenchymal stem cells (MSCs) are regarded as potent cells with a property of cartilage regeneration. We aimed to optimize marrow-derived MSC chondrogenic culture using a small bioactive molecule referred to as BIO. Methods: MSCs from the ma...

Background: Integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. Integrins are known to associate with a number of accessory molecules such as CD147 that may act to regu...

objective(s) articular cartilage tissue defects cannot be repaired by the proliferation of resident chondrocytes. autologous chondrocyte transplantation (act) is a relatively new therapeutic approach to cover full thickness articular cartilage defects by in vitro grown chondrocytes from the joint of a patient. therefore, we investigated the redifferentiation capability of human chondrocytes mai...

introduction: shark cartilage has been shown to have some inhibitory effects on angiogenesis, metastasis, cell adhesion and proteolysis. patients and methods: in this study, we evaluated the effect of shark cartilage on immune response in three treatment session of 3 weeks, 6 weeks and 12 weeks on stage iii invasive ductal carcinoma patients (n=15) compared to patients treated with a starch pla...

In article number 2100315 by Robert L. Mauck and co-workers, a hyaluronic acid (HA) system is used to modify the surface of damaged cartilage. This interdigitating microenvironment enhances multi-scale mechanics degenerated cartilage, restoring response chondrocytes within. modified tissue can then be improve adhesion behavior stem cells, providing route “seal” cartilage defects. Together, this...

background : in recent years tissue engineering developed to replace or repair damaged tissues using cell and biomaterial. one of the most important fields of tissue engineering is simulation of in vivo micro environment of body tissues. this study aimed to develop culture chamber and cell biomaterial sheet engineering for the reconstruction of cartilage tissue. methods : stainless steel cultur...

The fragment-size distributions of raw carrot diced or crushed using a food mixer are studied experimentally. For the 5-mm-square carrot, normal distribution shows characteristic feature fragmentation statistics. This simple result indicates that most random errors contribute to fluctuation. On other hand, for cumulative fragment size follows power law where exponent \(\alpha \simeq 1.62 > 1\)....