Dibenzo(a,n)pyrene, [DB(a,n)P], dibenzo(a,/)pyrene [DB(a,/)P], and seven of their benzo-ring derivatives were tested for tumorigenic activity on mouse skin and in newborn mice. In the tumor studies on mouse skin, a single topical application of 50, 200, or 600 nmol of compound was followed 7 days later by twice-weekly applications of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate for 1...

We present a study of the recent solar neutrino data using a Bayesian approach. The survival probability for neutrinos as a function of the energy has been extracted by two independent methods. The results of our analysis, assuming that only νe are observed in the Super-Kamiokande experiment, show a distinct supression of the survival probability at about 1 MeV, in good agreement with previous ...

A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABA(A) receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds. An azide group was obtained after two sequential reactions, and the central ring was closed via a nitrene to obtain the tricyclic sulfonamides (DBTDs). Whole-cell re...

Phthalimide was reacted with chlorosulfonic acid to give sulfonic acid-functionalized phthalimide (SFP), which characterized by 1H NMR, 13C NMR, FT-IR, XRD (X-ray diffraction), SEM (scanning electron microscopy), EDX (energy-dispersive X-ray), mass, TG (thermogravimetry) and DTG (derivative thermal gravimetry) spectra. Afterward, its catalytic activity was examined for the condensation of aryla...

thermal rearrangement of 7,7-dichloro-[a,c]-dibenzo-[4,1,0]-bicycloheptane (1) to 5,6-dichloro-5hdibenzo-[a,c]-cycloheptene (2) was studied in the solid phase and in solvents with different polarities. thefirst-order constants at various temperatures for the rearrangement process were evaluated from theabsorption time data. the activation parameters for this rearrangement were obtained from the...

Polycyclic aromatic compounds (PAC) are ubiquitous pollutants in urban air that may pose risks to human health. In order to better assess the health risks associated with this class of compounds, a total of 67 PAC that either have been identified (55) or are suspected to be present (12) in urban aerosol samples were tested for mutagenicity in a forward mutation assay based on human B-lymphoblas...