Nitrogen rich compounds are suitable as ingredients in low smoke propellant charges. Several high-N energetic materials are presented which are based on tetrazoles. Tetrazoles are an unique class of compounds, since they combine a high nitrogen content and a high heat of formation with good thermal and kinetic stabilities due to their aromatic ring system. The reaction of 5azidotetrazole with h...

Energetic materials (explosives, propellants, and pyrotechnics) are used extensively for both civilian and military applications and the development of such materials, particularly in the case of energetic salts, is subject to continuous research efforts all over the world. This Review concerns recent advances in the syntheses, properties, and potential applications of ionic salts based on tetr...

The inhibition of insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) by angiotenesin IV is known to improve memory and learning in rats. Screening 10 500 low-molecular-weight compounds in an enzyme inhibition assay with IRAP from Chinese Hamster Ovary (CHO) cells provided an arylsulfonamide (N-(3-(1H-tetrazol-5-yl)phenyl)-4-bromo-5-chlorothiophene-2-sulfonamide), comprising a tetrazole in the...

A readily accessible iridium(iii) phenyl-tetrazole complex ([Ir(ptrz)2(tBu-bpy)]+, 2; Hptrz = 2-methyl-5-phenyl-tetrazole; tBu-bpy = 4,4'-di-tert-butyl-2,2'-bipyridine) is shown to be a versatile catalyst for a new photocatalytic Michael reaction. Under light irradiation in the presence of 2, a dithiane 2-carboxylic acid, obtained by simple hydrolysis of a commercially available ethyl ester, ge...

The benzodiazepines (BZs) are the most widely used hypnotics. The thienobenzodiazepine derivative etizolam, 6-(o-chlorophenyl)-8ethyl-1-methyl-4H-s-triazolo[3,4-c]thieno[2,3-e] [1,4]diazepine, is a comparatively new potent anxiolytic and/or hypnotic [1]. The BZs have been considered largely free of neuro-endocrine effect [2]. However, hyperprolactinemia and galactorrhea have been suggested to b...

Objective: The objective of the study is to synthesize some novel 1,5-benzodiazepine derivatives from chalcones. The structures of the newly synthesized compounds were characterized by elemental analysis, infrared, 1H nuclear magnetic resonance, and mass spectroscopic studies. All titled compounds were screened for their anti-inflammatory activity. Methods: In this study, a series of novel 2-(s...

We report the direct observation of a bent geometry for a nonstabilized nitrile imine in a metal-coordination crystal. The photoinduced tetrazole ring rupture to release N(2) appears to depend on the size of voids around the N(3)-N(4) bond in the crystal lattice. We further observed the selective formation of the 1,3-addition product when a reactive nitrile imine was photogenerated in water. Ov...