نتایج جستجو برای: diabetic wound

تعداد نتایج: 178367  

Journal: :Molecular medicine reports 2011
Qing-Ling Zhong Fan-Rong Liu De-Wu Liu Yan Peng Xiang-Rong Zhang

The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction of β-catenin and its downstream target in ESCs, cyclin D1, lead to poor wound...

Journal: :Bulletin of mathematical biology 2006
Helen V Waugh Jonathan A Sherratt

Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for dia...

2016
Hamid Galehdari Samira Negahdari Mahnaz Kesmati Anahita Rezaie Gholamreza Shariati

BACKGROUND Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, beca...

Journal: :Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2018
Samuel R Nussbaum Marissa J Carter Caroline E Fife Joan DaVanzo Randall Haught Marcia Nusgart Donna Cartwright

OBJECTIVE The aim of this study was to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type and by setting. METHODS This retrospective analysis of the Medicare 5% Limited Data Set for calendar year 2014 included beneficiaries who experienced episodes of care for one or more of the following: arterial ulcers, chronic ulcers, diabetic foot ulcers, diab...

Journal: :International wound journal 2014
Joon Pio Hong Sung Woo Park

Diabetic wound is a chronic wound in which normal process of wound healing is interrupted. Lack of blood supply, infection and lack of functional growth factors are assumed as some of the conditions that lead to non-healing environment. Epidermal growth factor (EGF) acts primarily to stimulate epithelial cell growth across wound. Erythropoietin (EPO) is a haematopoietic factor, which stimulates...

2017
Ilya A Demyanenko Vlada V Zakharova Olga P Ilyinskaya Tamara V Vasilieva Artem V Fedorov Vasily N Manskikh Roman A Zinovkin Olga Yu Pletjushkina Boris V Chernyak Vladimir P Skulachev Ekaterina N Popova

Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes. However, the role of mitochondrial reactive oxygen species in this process is unknown. It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals. We have applied the mitochondria-targeted antioxidant 10-(6'-plasto...

2011
Sae Hee Ko Allison Nauta Shane D. Morrison Hongyan Zhou Andrew Zimmermann Geoffrey C. Gurtner Sheng Ding Michael T. Longaker

Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vit...

Journal: :The Annals of thoracic surgery 1997
K J Zerr A P Furnary G L Grunkemeier S Bookin V Kanhere A Starr

BACKGROUND Elevated blood glucose levels in the postoperative period are associated with an increased risk of deep wound infection in diabetic individuals undergoing open heart operations at Providence St. Vincent Hospital. METHODS Of 8,910 patients who underwent cardiac operations between 1987 and 1993, 1,585 (18%) were diabetic. The rate of deep sternal wound infections in diabetic patients...

2014
Harshavardhan Pathapati Gopala Krishna Murthy B. Ramanaiah

Objectives: Diabetes is a metabolic disorder mainly impairs the body glucose utilization capacity due to this perforcely repressing the immuno-dysfunction (decreases chemotaxis, phagocytosis and intracellular killing actions) and collagen synthesis which are essential in wound debridement management of diabetic patients. Delayed wound healing is considered as one of the most repulsive disabling...

2017
Kenji M Cunnion Neel K Krishna Haree K Pallera Angela Pineros-Fernandez Magdielis Gregory Rivera Pamela S Hair Brittany P Lassiter Ryan Huyck Mary A Clements Antoinette F Hood George T Rodeheaver Patrick S Cottler Jerry L Nadler Anca D Dobrian

Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor. The complement system (CS) is the most potent inflammatory cascade in humans and contributes to poor wound healing in animal models. Signal transducer and activator of transcription 4 (STAT4) is a tr...

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