Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.D...

background: diabetes mellitus is one of the most important diseases in all over the world. insulin and its receptor are found in specific area of cns with a variety of regions-specific functions different from its role in direct glucose regulation in the periphery. the hippocampus and cerebral cortex distributed insulin and insulin receptor has been shown to be involved in brain cognitive funct...

Mesenchymal stem cells (MSCs) have been used for therapy of type 1 diabetes mellitus. However, the in vivo distribution and therapeutic effects of transplanted MSCs are not clarified well. Herein, we reported that CdSe/ZnS quantum dots-labeled MSCs were prepared for targeted fluorescence imaging and therapy of pancreas tissues in rat models with type 1 diabetes. CdSe/ZnS quantum dots were synth...

BACKGROUND The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS The efficacy of herbal cream containing Pelargonium graveolens and Oliveria deco...

Introduction: Diabetes mellitus is associated with nervous system alterations in both human and animal models. This study was done to determine the effect of gestational diabetes on the Purkinje and granular cells in the cerebellum of rat offspring.  Methods: 10 Wistar rats Dams were randomly allocated in control and diabetic group. The experimental group received 40 mg/kg/body wei...

background: the relationship between the high activity of aldose reductase (ar) and diabetic cataract formation has been previously investigated. the purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (stz)-induced diabetic cataract in rats. methods: 34 adult healthy male sprague-dawely rats were divided into four groups. diabetic control and diab...

BACKGROUND/AIMS Abnormal visceral sensitivity and disordered motility are common in patients with diabetes mellitus. The purpose of the present study was to investigate whether visceral sensation and bowel motility were altered in a rat model of type 2 diabetes mellitus accompanied by weight loss. METHODS A type 2 diabetic rat model in adulthood was developed by administrating streptozotocin ...

BACKGROUND Hypertension has been associated to diabetes, and participates in the development of diabetic complications. The spontaneously hypertensive rat (SHR) is the gold standard model for the study of hypertension, and experimental diabetes has been currently investigated in SHR. Wistar-Kyoto rat is usually taken as control for SHR, however, regarding the glycemic homeostasis, WKY may be si...

Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxid...