Diabetic peripheral and autonomic neuropathies are common complications of diabetes with broad spectrums of clinical manifestations and high morbidity. Studies using various agents to target the pathways implicated in the development and progression of diabetic neuropathy were promising in animal models. In humans, however, randomized controlled studies have failed to show efficacy on objective...

Although over the years the considerable breakthroughs made in our understanding of diabetic neuropathy has come from both neurologists and diabetologists, in recent times (in the UK) it is diabetologists that have assumed the main clinical role in diagnosing and managing the most common neuropathy in the western world. It may therefore be that referral of patients with diabetic neuropathy from...

The quality of life (QOL) of 79 people with type 1 and type 2 diabetes and 37 non-diabetic controls was assessed using the Nottingham Health Profile (NHP). The NHP consists of six domains assessing energy, sleep, pain, physical mobility, emotional reactions and social isolation. Symptomatic diabetic neuropathy was present in 41 of the patients. The neuropathy patients had significantly higher s...

a diagnostic percolation and approach to the correct methods of approach in Peripheral Neuropathy, has currently advanced. the newer concepts in diagnosis, especially with the advent of Neurophysiological studies and imaging studies skin biopsy has totally revolutionalized the diagnosis of peripheral neuropathy to a remarkable level. it is also observed that various newer theories of pathophysi...

over the past three decades physicians have used light level laser therapy (lllt) for the management and the treatment of diabetic peripheral neuropathy and have obtained results that calls for further investigations. this study aimed to investigate the effectiveness of lllt in treatment of pain symptoms in patients with diabetic polyneuropathy. in this study 60 patients with diabetic periphera...

Diabetic neuropathy, the most common peripheral neuropathy in the Western world, is responsible for most limb amputations and considerable morbidity in diabetic patients. Although it is a sequela to insulin deficiency and/or hyperglycemia, its exact pathogenetic mechanism remains unclear. Therapy is directed at early diagnosis, exclusion of other neuropathic disorders, prudent glucose control, ...

Diabetic neuropathy develops as a result of hyperglycemia-induced local metabolic and microvascular changes in both type I and type II diabetes mellitus. Diabetic neuropathy shows slower impulse conduction, axonal degeneration, and impaired regeneration. Diabetic neuropathy affects peripheral, central, and visceral sensorimotor and motor nerves, causing improper locomotor and visceral organ dys...

Pain symptoms are a common complication of diabetic peripheral neuropathy or an inflammatory condition. In the most experiments, only one or two evident pain modalities are observed at diabetic peripheral neuropathy according to experimental conditions. Following diabetic peripheral neuropathy or inflammation, spinal glial activation may be considered as an important mediator in the development...

Using the Toronto Diabetic Neuropathy Expert Group-2010 classification of diabetic peripheral neuropathy (DPN), 89% of patients with newly diagnosed type2 diabetes had either confirmed or subclinical-DPN, hence at increased risk of foot complications. Sudomotor-dysfunction (SMD) assessed through electrochemical skin-conductance measurement was present in51.1%. SMD has 73% sensitivity and 81% NP...