Neuropathy is a common complication of diabetes and is characterised by a progressive loss of peripheral nerve fibres. 2 There are a number of manifestations including both monoand polyneuropathies. In the diabetic foot, distal sensory polyneuropathy is seen most commonly. However, motor and autonomic fibres may also be involved and combined neuropathies frequently occur. The development of a n...

in wistar rats, reproductive behavior is controlled in a neural circuit of ventral forebrain including the medial amygdala (me), bed nucleus of the stria terminalis (bnst) and medial preoptic area (mpoa) via perception of social odors. diabetes mellitus (dm) is a widespread metabolic disease that affects many organs in a variety of levels. dm can cause central neuropathies such as neuronal apop...

Inclusion of Prameha among the eight major disorders in Charaka Samhita shows the importance of the disease given by ancient seers. The risk of development of blindness in diabetics increases by 20-25 times as compared to the normal population. High prevalence rate of Diabetic Retinopathy (34.6%), proliferative diabetic retinopathy (7%), diabetic macular edema (6.8%), and Vision threatening Dia...

Despite its limited therapeutic use, several research reports indicate that TCC is currently the most rapid and effective technique for healing diabetic neuropathic ulcers. Skilled application and careful follow-up of the wound are necessary to avoid complications and minimize the risks for reulceration. As more clinicians adopt this form of therapy, the successful treatment of neuropathic ulce...

Background: Intermittent claudication mainly attributable to peripheral arterial disease is the experiencing of pain in legs, especially calf muscles, during walking and diabetic peripheral neuropathies are the commonest sequelae of diabetes mellitus. Diabetic peripheral neuropathies affect up to 50% of US patients with type 1 and type 2 diabetes mellitus. The purpose of the current study was t...

Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ul...

INTRODUCTION The activity of erythrocyte transketolase induced by thiamine pyrophosphate and normalized to age of the patient is a marker of thiamine metabolism disturbances with pathological consequences in the central and peripheral nervous system. The measurement of erythrocyte transketolase activity enables evaluation of the thiamine status and therapeutic decisions in the disorders of the ...

Diabetes targets the peripheral nervous system with several different patterns of damage and several mechanisms of disease. Diabetic polyneuropathy (DPN) is a common disorder involving a large proportion of diabetic patients, yet its pathophysiology is controversial. Mechanisms considered have included polyol flux, microangiopathy, oxidative stress, abnormal signaling from advanced glycation en...