OBJECTIVE Subjects with diabetes mellitus are at high risk for developing atherosclerosis through a variety of mechanisms. Because the metabolism of glucose results in production of activators of protein kinase C (PKC)β, it was logical to investigate the role of PKCβ in modulation of atherosclerosis in diabetes mellitus. APPROACH AND RESULTS ApoE(-/-) and PKCβ(-/-)/ApoE(-/-) mice were rendere...

OBJECTIVE Diabetes mellitus causes bone marrow (BM) microangiopathy. This study aimed to investigate the mechanisms responsible for BM endothelial dysfunction in diabetes mellitus. METHODS AND RESULTS The analysis of differentially expressed transcripts in BM endothelial cells (BMECs) from type-1 diabetic and nondiabetic mice showed an effect of diabetes mellitus on signaling pathways control...

abstract   introduction: diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. considering the beneficial antidiabetic potential of nigella sativum (ns ), this research study was conducted to evaluate the effect of chronic consumption of ns on learning and memory in diabetic rats using passive avoidance and y-maz...

  Abstract  Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard forma...

AIM To determine the prevalence of diabetic retinopathy in patients with Down's syndrome and diabetes mellitus. METHODS Nine patients with Down's syndrome and diabetes mellitus were assessed. Factors recorded included type and duration of diabetes, level of diabetic control, blood pressure, urinalysis, and results of ophthalmological examination. RESULTS The duration of diabetes ranged from...

OBJECTIVES To present the main mechanisms that cause gastrointestinal symptoms in patients with diabetes mellitus, their frequency, and controversies as to their occurrence in children and adolescents. SOURCES Non-systematic review of the literature conducted in the MEDLINE/PubMed and SciELO databases (1983-2011), as well as relevant book chapters. The most relevant and up-to-date articles on...

Introduction: Autonomic neuropathy is less well documented in children with type 1 diabetes mellitus and has received less attention than other diabetic complications. Sudden death and cardio-respiratory arrest in patients with type 1 and type 2 diabetes mellitus have b cardiac autonomic dysfunction. Aim: The aim of this study was to determine the prevalence of autonomic neuropathy in a cohort ...

A relationship has been reported between trace elements and diabetes mellitus. This study evaluated the role of such a relationship in 83 patients with non-insulin dependent diabetes mellitus (40 men and 43 women), with a mean duration of diabetes of 3.9 +/- 3.6 years. Patients with nephropathy were excluded. Thirty healthy non-diabetic subjects were studied for comparative analysis. Subjects w...

Diabetes mellitus is characterized by altered blood sugar homeostasis. A chronic metabolic disorder affecting millions of people worldwide. Diabetic mortality rates are escalating in developed countries the clock. Till...