Accepted for publication 26 June 2003 . . . . . . . . . . . . . . . . . . . . . . . R educing the incidence and slowing the progression of diabetes related microvascular complications remains a difficult challenge. In the case of diabetic retinopathy, tight glucose and blood pressure control are difficult to achieve and maintain in practice, yet still only provide partial protection against sig...

Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called "connexins." In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms ...

background: cell-based treatments are currently being actively received great attention among scientists and clinicians for a variety of diseases as well as diabetes .the aim of this study was to investigate the effect of allotransplantation of fetal liver-derived cell suspension in patients with type 1 diabetes. methods: patients with type 1 diabetes (n=16) aged 6-30 years-old were included in...

Coexistent type 2 diabetes and obesity—often termed “diabesity”—is an emerging epidemic that poses a challenge to the treatment of both conditions.More than 90% of the world’s 285 million people with diabetes have type 2 diabetes, and this number is projected to grow to 438 million by 2030. In North America about 90% of people with type 2 diabetes are obese (body mass index >30 (weight (kg)/hei...

Research Letters Association between age and the initiation of antihypertensive, lipid lowering and antiplateletet medications in elderly individuals newly treated with antidiabetic drugs SIR—The elderly are the age group most affected by diabetes mellitus [1]. Given that the general population is age-ing, the number of older individuals with diabetes is likely to increase. Moreover, diabetes i...

OBJECTIVE To estimate the health utility scores associated with type 2 diabetes, its treatments, complications, and comorbidities. RESEARCH DESIGN AND METHODS We analyzed health-related quality-of-life data, collected at baseline during Translating Research Into Action for Diabetes, a multicenter, prospective, observational study of diabetes care in managed care, for 7,327 individuals with ty...

diabetic retinopathy is the leading cause of blindness in the world. strict control of blood sugar, blood pressure, laser therapy, pharmacotherapy and vitrectomy are of among common diabetic retinopathy treatments. further studies to investigate the effect of protein kinase c inhibitors, angiotensin converting enzyme inhibitors, growth hormone and other proposed treatments for diabetic retinopa...